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228 Cards in this Set

  • Front
  • Back
Fetal landmarks Day 0
Fertilization by sperm, initiating embryogenesis.
Fetal landmarks Within week 1
Implantation (as a blastocyst).
Fetal landmarks Within week 2
Bilaminar disk (epiblast:hypoblast).
Fetal landmarks Within week 3
Gastrulation. Primitive streak, notochord, and neural plate begin to form.
Fetal landmarks Weeks 3–8 wrt
Neural tube formed. Organogenesis. Extremely susceptible to teratogens.
Fetal landmarks Week 4
Heart begins to beat: 4 chambers in week 4. Upper and lower limb buds begin to form.
Fetal landmarks Week 8
Fetal movement; fetus looks like a baby.
Fetal landmarks Week 10
Genitalia have male/female characteristics.
Fetal landmarks plates with functions
Alar plate - Sensory Basal plate - Motor
Fetal landmarks first week
Fertilization - day 1 Zygote - day 2 Morula - day 3 blastocyst - day 5 implantation - day 6
Fetal landmarks when does the following occur Implantation (as a blastocyst).
within week 1
Fetal landmarks when does the following occur Bilaminar disk (epiblast:hypoblast).
Within week 2
Fetal landmarks when does the following occur Primitive streak, notochord, and neural plate begin to form.
Within week 3
Fetal landmarks when does the following occur Gastrulation.
Within week 3
Fetal landmarks when does the following occur Neural tube formed.
Weeks 3–8
Fetal landmarks when does the following occur Organogenesis.
Weeks 3–8
Fetal landmarks when does the following occur Extremely susceptible to teratogens.
Weeks 3–8
Fetal landmarks when does the following occur Heart begins to beat
week 4 4 chambers in week 4.
Fetal landmarks when does the following occur Upper and lower limb buds begin to form.
Week 4
Fetal landmarks when does the following occur fetus looks like a baby.
Week 8
Fetal landmarks when does the following occur Fetal movement
Week 8
Fetal landmarks when does the following occur Genitalia have male/female characteristics.
Week 10
Rule of 2’s for 2nd week
--2 germ layers (bilaminar disk): epiblast, hypoblast. --2 cavities: amniotic cavity, yolk sac. --2 components to placenta: cytotrophoblast, syncytiotrophoblast.
The epiblast precursor to what and what it does/forms
(precursor to ectoderm) invaginates to form primitive streak. Cells from the primitive streak give rise to both intraembryonic mesoderm and endoderm.
invaginates to form primitive streak. Cells from the primitive streak give rise to both intraembryonic mesoderm and endoderm.
The epiblast (precursor to ectoderm)
Rule of 3’s for 3rd week
3 germ layers (gastrula): ectoderm, mesoderm, endoderm.
Embryologic derivatives Mesodermal defects =
VACTERL: Vertebral defect, Anal atresia, Cardiac defects, Tracheo-Esophageal fistula, Renal defects, Limb defects (bone and muscle).
Embryologic derivatives Surface ectoderm
Adenohypophysis; lens of eye; epithelial linings of skin, ear, eye, and nose; epidermis.
Embryologic derivatives Neuroectoderm
Neurohypophysis, CNS neurons, oligodendrocytes, astrocytes, ependymal cells, pineal gland.
Embryologic derivatives Neural crest
ANS, dorsal root ganglia, melanocytes, chromaffin cells of adrenal medulla, enterochromaffin cells, pia and arachnoid, celiac ganglion, Schwann cells, odontoblasts, parafollicular (C) cells of thyroid, laryngeal cartilage, bones of the skull
Embryologic derivatives Endoderm
Gut tube epithelium and derivatives (e.g., lungs, liver, pancreas, thymus, parathyroid, thyroid follicular cells).
Embryologic derivatives Notochord
Induces ectoderm to form neuroectoderm (neural plate). Its only postnatal derivative is the nucleus pulposus of the intervertebral disk.
Embryologic derivatives Mesoderm
Dura mater, connective tissue, muscle, bone, cardiovascular structures, lymphatics, blood urogenital structures, serous linings of body cavities (e.g., peritoneal), spleen, adrenal cortex, kidneys.
7. Common congenital malformations
1. Heart defects 2. Hypospadias 3. Cleft lip (with or without cleft palate) 4. Congenital hip dislocation 5. Spina bifida 6. Anencephaly 7. Pyloric stenosis
Associated with projectile vomiting.
Pyloric stenosis
Teratogens effect/cause Alcohol
Birth defects and mental retardation (leading cause); fetal alcohol syndrome
Teratogens effect/cause mental retardation (leading cause)
Alcohol
Teratogens effect/cause ACE inhibitors
Renal damage
Teratogens effect/cause Renal damage
ACE inhibitors
Teratogens effect/cause Abnormal fetal development and fetal addiction
Cocaine
Teratogens effect/cause Cocaine
Abnormal fetal development and fetal addiction
Teratogens effect/cause Vaginal clear cell adenocarcinoma
Diethylstilbestrol (DES)
Teratogens effect/cause Diethylstilbestrol (DES)
Vaginal clear cell adenocarcinoma
Teratogens effect/cause Iodide
Congenital goiter or hypothyroidism
Teratogens effect/cause Congenital goiter or hypothyroidism
Iodide
Teratogens effect/cause 13-cis-retinoic acid
Extremely high risk for birth defects (hearing and visual impairment, missing earlobes, facial dysmorphism, and mental retardation)
Teratogens effect/cause Extremely high risk for birth defects (hearing and visual impairment, missing earlobes, facial dysmorphism, and mental retardation)
13-cis-retinoic acid
Teratogens effect/cause Thalidomide
Limb defects (“flipper” limbs)
Teratogens effect/cause Limb defects (“flipper” limbs)
Thalidomide
Teratogens effect/cause Tobacco
Preterm labor, placental problems, attention-deficit hyperactivity disorder (ADHD)
Teratogens effect/cause Preterm labor, placental problems, attention-deficit hyperactivity disorder (ADHD)
Tobacco
Teratogens effect/cause Warfarin
multiple
Teratogens effect/cause anticonvulsants
multiple
Teratogens effect/cause Xrays
multiple
Teratogens effect/cause multiple
Warfarin, x-rays, anticonvulsants
FAS what are the defects
craniofacial abnormalities microcephaly limb dislocation heart and lung fistulas
FAS mech
unknown, but may include inhibition of cell migration
Umbilical cord contents and where the blood comes from/goes
Contains 2 umbilical arteries, which return deoxygenated blood from fetal internal iliac arteries, and 1 umbilical vein, which supplies oxygenated blood from the placenta to the fetus.
Allantoic duct role
removes nitrogenous waste (from fetal bladder, like a urethra).
Single umbilical artery is associated with
congenital and chromosomal anomalies.
Umbilical cord structure and congenital and chromosomal anomalies.
Single umbilical artery is associated with congenital and chromosomal anomalies.
Wharton´s jelly what, derivation, structure and function
a gelatinous substance within the umbilical cord, composed of cells that originate in the original egg and sperm of conception. It is largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). As a mucous tissue it protects and insulates umbilical blood vessels.
Heart embryology what this gives rise to Truncus arteriosus
Ascending aorta and pulmonary trunk
Heart embryology what this gives rise to Bulbus cordis
Smooth parts of left and right ventricle
Heart embryology what structures arise from the Primitive ventricle
Trabeculated parts of left and right ventricle
Heart embryology what this gives rise to Primitive atria
Trabeculated left and right atrium
Heart embryology what this gives rise to Left horn of sinus venosus (SV)
Coronary sinus
Heart embryology what this gives rise to Right horn of SV
Smooth part of right atrium
Heart embryology what this gives rise to Right common cardinal vein and right anterior cardinal vein
SVC
What embyonic structure gives rise to Ascending aorta and pulmonary trunk
Truncus arteriosus
What embyonic structure gives rise to Smooth parts of left and right ventricle
Bulbus cordis
What embyonic structure gives rise to Trabeculated parts of left and right ventricle
Primitive ventricle
What embyonic structure gives rise to Trabeculated left and right atrium
Primitive atria
What embyonic structure gives rise to Coronary sinus
Left horn of sinus venosus (SV)
What embyonic structure gives rise to Smooth part of right atrium
Right horn of SV
What embyonic structure gives rise to SVC
Right common cardinal vein and right anterior cardinal vein
Fetal erythropoiesis by time frame
Young Liver Synthesizes Blood. Fetal erythropoiesis occurs in: 1. Yolk sac (3–8 wk) 2. Liver (6–30 wk) 3. Spleen (9–28 wk) 4. Bone marrow (28 wk onward)
Fetal hemoglobin = Adult hemoglobin =
Fetal hemoglobin =α2γ2. (gamma) Adult hemoglobin =α2β2.
Fetal component of the placenta and where/function
cytotrophoblast composes the inner layer of chorionic villi. Syncytiotrophoblast is the outer layer and secretes hCG
placenta what is the outer layer and secretes hCG
Syncytiotrophoblast
placenta what composes the inner layer of chorionic villi
cytotrophoblast
maternal component of the placenta
Decidua basalis derived from the endometrium
steps in the interventricular septum development
1. muscular interventricular septum forms with an interventricular foramen 2.(twisting)aorticopulmonary septum devides the truncus into the 2 trunks 3. 2 septums meet, fuse, become membranous, and close the interventricular foramen
Fetal circulation 3 important shunts:
foramen ovale ductus arteriosis ductus venosus
Fetal circulation foramen ovale
Most oxygenated blood reaching the heart via the IVC is diverted through the foramen ovale and pumped out the aorta to the head.
Fetal circulation ductus arteriosis
Deoxygenated blood from the SVC is expelled into the pulmonary artery and ductus arteriosus to the lower body of the fetus.
Fetal circulation ductus venosus
Blood entering the fetus hrough the umbilical vein s conducted via the ductus venosus into the VC.
Fetal circulation changes at birth
infant takes a breath; ↓ resistance in pulmonary vasculature causes ↑ left atrial pressure vs. right atrial pressure; foramen ovale closes; ↑ in O2 leads to ↓ in prostaglandins, causing closure of ductus arteriosus.
drugs to open or close PDA
Indomethacin closes the PDA. Prostaglandins keep a patent PDA open.
Fetal/postnatal corresponding structure Umbilical vein
ligamentum teres hepatis
Fetal/postnatal corresponding structure ligamentum teres hepatis
Umbilical vein
Fetal/postnatal corresponding structure Umbilical arteries
mediaL umbilical ligaments
Fetal/postnatal corresponding structure medial umbilical ligaments
UmbiLical arteries
Fetal/postnatal corresponding structure Ductus arteriosus
––ligamentum arteriosum
Fetal/postnatal corresponding structure ligamentum arteriosum
Ductus arteriosus
Fetal/postnatal corresponding structure Ductus venosus
ligamentum venosum
Fetal/postnatal corresponding structure ligamentum venosum
Ductus venosus
Fetal/postnatal corresponding structure Foramen ovale
fossa ovalis
Fetal/postnatal corresponding structure fossa ovalis
Foramen ovale
Fetal/postnatal corresponding structure median umbilical ligament
AllaNtois––urachus––mediaN umbilical ligament
Fetal/postnatal corresponding structure Allantois
AllaNtois––urachus––mediaN umbilical ligament
Fetal/postnatal corresponding structure Notochord
nucleus pulposus of intervertebral disk
Fetal/postnatal corresponding structure nucleus pulposus of intervertebral disk
Notochord
Fetal/postnatal corresponding structure Urachal cyst or sinus is a remnant.
The urachus
What is contained in the falciform ligament
round ligament and paraumbilical veins.
The urachus is the part of
the allantoic duct between the bladder and the umbilicus.
what is part of the allantoic duct between the bladder and the umbilicus.
urachus
Aortic arch derivatives 1st
part of MAXillary artery.
Aortic arch derivatives part of MAXillary artery.
1st
Aortic arch derivatives 2nd
Stapedial artery and hyoid artery.
Aortic arch derivatives Stapedial artery and hyoid artery.
2nd
Aortic arch derivatives 3rd
common Carotid artery and proximal part of internal carotid artery.
Aortic arch derivatives common Carotid artery and proximal part of internal carotid artery.
3rd
Aortic arch derivatives 4th
on left, aortic arch; on right, proximal part of right subclavian artery.
Aortic arch derivatives on left, aortic arch; on right, proximal part of right subclavian artery.
4th
Aortic arch derivatives 6th
proximal part of pulmonary arteries and (on left only) ductus arteriosus.
Aortic arch derivatives proximal part of pulmonary arteries and (on left only) ductus arteriosus.
6th
Aortic arch derivatives mnemonic
-1st arch is MAXimal. -Second = Stapedial. -C is 3rd letter of alphabet. -4th arch (4 limbs)=systemic. -6th arch = pulmonary and the pulmonary-to-systemic shunt (ductus arteriosus).
Branchial apparatus different parts and what they are from
Branchial clefts are derived from ectoderm. Branchial arches are derived from mesoderm and neural crests. Branchial pouches are derived from endoderm.
Branchial apparatus aka/s
Branchial apparatus is also called pharyngeal apparatus. Clefts are also called grooves.
pharyngeal apparatus aka/s
Branchial apparatus is also called pharyngeal apparatus. Clefts are also called grooves.
Branchial apparatus layers
CAP covers outside from inside (Clefts = ectoderm, Arches = mesoderm, Pouches = endoderm).
Branchial arch 1 derivatives muscles
Meckel’s cartilage: Mandible, Malleus, incus, sphenoMandibular ligament.
Branchial arch 1 derivatives cartilage
Muscles: Muscles of Mastication (temporalis, Masseter, lateral and Medial pterygoids) Mylohyoid, anterior belly of digastric, tensor tympani, tensor veli palatini, anterior 2⁄3 of tongue.
Branchial arch 1 derivatives nerves
Nerve: CN V2 and CN V3.
Branchial arch 2 derivatives muscles
Reichert’s cartilage: Stapes, Styloid process, lesser horn of hyoid, Stylohyoid ligament.
Branchial arch 2 derivatives cartilage
Muscles: muscles of facial expression, Stapedius, Stylohyoid, posterior belly of digastric.
Branchial arch 2 derivatives nerves
Nerve: CN VII.
Branchial arch 3 derivatives muscles
Cartilage: greater horn of hyoid.
Branchial arch 3 derivatives cartilage
Muscle: stylopharyngeus.
Branchial arch 3 derivatives nerves
Nerve: CN IX.
Branchial arch 4,6 derivatives cartilages
Cartilages: thyroid, cricoid, arytenoids, corniculate, cuneiform.
Branchial arch 4 derivatives muscles
Muscles (4th arch): most pharyngeal constrictors, cricothyroid, levator veli palatini.
Branchial arch 4 derivatives nerves
Nerve: 4th arch––CN X (superior laryngeal branch);
Branchial arch 6 derivatives muscles
Muscles (6th arch): all intrinsic muscles of larynx except cricothyroid.
Branchial arch 6 derivatives nerves
6th arch––CN X (recurrent laryngeal branch).
which Branchial arches form posterior 1/3 of tongue.
Arches 3 and 4
which Branchial arch Meckel’s cartilage: Mandible, Malleus, incus, sphenoMandibular ligament.
1
which Branchial arch Muscles: Muscles of Mastication (temporalis, Masseter, lateral and Medial pterygoids), Mylohyoid, anterior belly of digastric, tensor tympani, tensor veli palatini, anterior 2⁄3 of tongue.
1
which Branchial arch Nerve: CN V2 and CN V3.
1
which Branchial arch Reichert’s cartilage: Stapes, Styloid process, lesser horn of hyoid, Stylohyoid ligament.
2
which Branchial arch are the following mm derived from: muscles of facial expression, Stapedius, Stylohyoid, posterior belly of digastric.
2
which Branchial arch Nerve: CN VII.
2
which Branchial arch Cartilage: greater horn of hyoid.
3
which Branchial arch Muscle: stylopharyngeus.
3
which Branchial arch Nerve: CN IX.
3
which Branchial arch Cartilages: thyroid, cricoid, arytenoids, corniculate, cuneiform.
6-Apr
which Branchial arch Muscles: most pharyngeal constrictors, cricothyroid, levator veli palatini.
(4th arch)
which Branchial arch Muscles : all intrinsic muscles of larynx except cricothyroid.
(6th arch)
which Branchial arch CN X (superior laryngeal branch)
4th
which Branchial arch CN X (recurrent laryngeal branch).
6th
which Branchial arch makes no major developmental contributions.
Arch 5
Branchial arch innervation and implications
Arch 1 -- CN V2 and V3. Arch 2 -- CN VII. Arch 3 -- CN IX. Arch 4 and 6 --CN X. with the exception of V2(no motor) these are the only CN's that have both sensory and motor components
Tongue development wrt arches and sensation/taste
1st branchial arch forms anterior 2/3 (thus sensation via CN V3, taste via CN VII). 3rd and 4th arches form posterior 1/3 (thus sensation and taste mainly via CN IX, extreme posterior via CN X).
Tongue motor innervation
Motor innervation is via CN XII.
Taste sensory nucleus of the brain and CN's
Taste is CN VII, IX, X (solitary nucleus);
Pain and motor innervation of the tounge
pain is CN V3, IX, X; motor is CN XII.
Branchial cleft derivatives 1st
1st cleft develops into external auditory meatus.
Branchial cleft derivatives 2nd-4th
2nd through 4th clefts form temporary cervical sinuses which are obliterated by proliferation of 2nd arch mesenchyme.
Persistent cervical sinus can lead to what and where
a branchial cyst in the lateral neck. Thyroglossal duct cyst in midline neck.
Ear development Bones
Malleus/incus–– 1st arch Stapes––2nd arch
Ear development Muscles
Tensor tyMpani (V3)––1st arch Stapedius (VII)––2nd arch
Ear development External auditory meatus
1st cleft
Ear development eustachian tube
Eardrum, eustachian tube––1st branchial membrane
Ear development Eardrum
Eardrum, eustachian tube––1st branchial membrane
branchial membranes
are located at junctions of clefts with pouches
are located at junctions of clefts with pouches
branchial membranes
Branchial pouch derivatives 1st pouch
middle ear cavity, eustachian tube, mastoid air cells.
Branchial pouch derivatives middle ear cavity, eustachian tube, mastoid air cells.
1st pouch
Branchial pouch derivatives 2nd pouch
develops into epithelial lining of palatine tonsil.
Branchial pouch derivatives develops into epithelial lining of palatine tonsil.
2nd pouch
Branchial pouch derivatives 3rd pouch
3rd pouch (dorsal wings) develops into inferior parathyroids. 3rd pouch (ventral wings) develops into thymus.
Branchial pouch derivatives develops into inferior parathyroids.
3rd pouch (dorsal wings)
Branchial pouch derivatives develops into thymus.
3rd pouch (ventral wings)
Branchial pouch derivatives 4th pouch
develops into superior parathyroids.
Branchial pouch derivatives develops into superior parathyroids.
4th pouch
Branchial pouch Aberrant development of 3rd and 4th pouches →
DiGeorge syndrome
Branchial derivatives DiGeorge syndrome
Aberrant development of 3rd and 4th pouches
Thyroid development arises from and movement
Thyroid diverticulum arises from floor of primitive pharynx, descends into neck.
Thyroid development WRT tounge
Connected to tongue by thyroglossal duct, which normally disappears but may persist as pyramidal lobe of thyroid.
Thyroid development wrt normal remnant
persist as pyramidal lobe of thyroid. Foramen cecum is normal remnant of thyroglossal duct.
Most common ectopic thyroid tissue
the tongue.
Cleft lip
failure of fusion of the maxillary and medial nasal processes (formation of 1° palate).
failure of fusion of the maxillary and medial nasal processes (formation of 1° palate).
Cleft lip
Cleft palate
failure of fusion of the lateral palatine processes, the nasal septum, and/or the median palatine process (formation of 2° palate).
failure of fusion of the lateral palatine processes, the nasal septum, and/or the median palatine process (formation of 2° palate).
Cleft palate
Diaphragm embryology derivations
Several Parts Build Diaphragm. 1. Septum transversum 2. Pleuroperitoneal folds 3. Body wall 4. Dorsal mesentery of esophagus
Diaphragm migration
Diaphragm descends during development but maintains innervation from C3–C5. “C3, 4, 5 keeps the diaphragm alive.”
Pancreas is derived from the
foregut
Pancreas where the different parts derive from
Ventral pancreatic bud becomes pancreatic head, uncinate process (lower half of head), and main pancreatic duct. Dorsal pancreatic bud becomes everything else (body, tail, isthmus, and accessory pancreatic duct).
Spleen arises from/blood supply
dorsal mesentery but is supplied by artery of foregut.
Annular pancreas
ventral and dorsal pancreatic buds abnormally encircle duodenum;forms a ring of pancreatic tissue that may cause duodenal narrowing.
ventral and dorsal pancreatic buds abnormally encircle duodenum;forms a ring of pancreatic tissue that may cause duodenal narrowing.
Annular pancreas
borders from foregut to hind gut
1. Foregut––pharynx to duodenum 2. Midgut––duodenum to transverse colon 3. Hindgut––distal transverse colon to rectum
Kidney embryology
1. Pronephros––week 4 then degenerates 2. Mesonephros––first trimester then contributes to male genital system 3. Metanephros––permanent
Mesonephric (wolffian) duct becomes
SEED. Seminal vesicles, Epididymis, Ejaculatory duct, and Ductus deferens.
Mesonephric duct aka
wolffian duct
wolffian duct aka
Mesonephric duct
Paramesonephric duct aka
müllerian duct
müllerian duct aka
Paramesonephric duct
Paramesonephric (müllerian) duct becomes
Develops into fallopian tube, uterus, and part of vagina.
Develops into fallopian tube, uterus, and part of vagina.
Paramesonephric (müllerian) duct
Develops into Seminal vesicles, Epididymis, Ejaculatory duct, and Ductus deferens.
Mesonephric (wolffian) duct
Müllerian inhibiting substance secreted by/for
by testes suppresses development of paramesonephric ducts in males.
↑ androgens cause development of ?????? ducts.
Mesonephric (wolffian) duct
what cause development of mesonephric ducts.
↑ androgens
Male detrmining gene and process
SRY gene on Y Chr codes for testis-determining factor. leads to Müllerian inhibiting substance secreted by testes suppresses development of paramesonephric ducts in males.
male homolog of Glans clitoris
Glans penis
male homolog of Vestibular bulbs
Corpus spongiosum
male homolog of Greater vestibular glands (of Bartholin)
Bulbourethral glands (of Cowper)
male homolog of Urethral and paraurethral glands (of Skene)
Prostate gland
male homolog of Labia minora
Ventral shaft of penis (penile urethra)
male homolog of Labia majora
Scrotum
female homolog of Glans penis
Glans clitoris
female homolog of Corpus spongiosum
Vestibular bulbs
female homolog of Bulbourethral glands (of Cowper)
Greater vestibular glands (of Bartholin)
female homolog of Prostate gland
Urethral and paraurethral glands (of Skene)
female homolog of Ventral shaft of penis (penile urethra)
Labia minora
female homolog of Scrotum
Labia majora
Male/female genital homologues what drives it towards male vs female
Dihydrotestosterone vs Estrogen
In the male what does the Genital tubercle become
Glans penis
In the male what does the Urogenital sinus become
-Corpus spongiosum -Bulbourethral gland (of Cowper) -Prostate gland
In the male what does the Urogenital folds become
Ventral shaft of penis (penile urethra)
In the male what does the Labioscrotal swelling become
Scrotum
In the female what does the Genital tubercle become
Glans clitoris
In the female what does the Urogenital sinus become
-Vestibular bulbs -Greater vestibular glands (of Bartholin) -Urethral and paraurethral glands (of Skene)
In the female what does the Urogenital folds become
Labia minora
In the female what does the Labioscrotal swelling become
Labia majora