Ecm

Front 1

Fibroblast

Back 1

1. most common ECM connective cell
2. locally produce matrix
3. cytoskeleton aligns with ECM fibers

Front 2

Chondroblast

Back 2

1. forms carilage
2. holds water
3. resilient
4. avascularized

Front 3

Osteoblast

Back 3

1. Forms bone
2. mineral precipitation
3. highly vascularized

Front 4

Collagen

Back 4

1. major protein fiber
2. very rigid and stable
3. orientation guided by fibroblast and co-secreted matrix molecules

Front 5

Structure of collagen

Back 5

1. triple stranded helix
2. each strand=fibril
3. 20 types based on 25 fibrils

Front 6

Elastin

Back 6

1. allows for tissues to be stretched
2. usually mixed with collagen
3. protein fiber

Front 7

Fibronectin

Back 7

1. protein fiber
2. attaches cells to matrix
plasma fibonectin
fibronectin fibrils
3. sequence recognized by integrins

Front 8

Laminin

Back 8

1. Helps form the basal lamina
2. mainly underneath epitheluim
3. regulate cell migration and orientation

Front 9

Glycoaminoglycans(GAG)

Back 9

1. long sugar chains
2. repeating disaccharides
3. lots of neg charge(polar)
4. extremely hydrophilic, lypophobic

Front 10

Hyaluronan

Back 10

1. simplest GAG
2. little branching, few protein link
3. prevelent during early development
4. readily fills space but resists compression(resilience in cartilage)

Front 11

Proteoglycans

Back 11

1. GAGs covalently linked to proteins'
2. function in
1. support
2. filtering
3. growth factor signaling
4. regulate secreted protein activity