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15 Cards in this Set
- Front
- Back
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COMT I -Pone |
Prolongs on time AE- sleep disturbances, orange colored urine Talcopone- inc liver enzymes- acute hepatic failure |
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Levodopa toxicity |
1) GIT- anorexia, nausea, emesis 2) CVS- postural hypotension, tachycardia, asystole, cardiac arrhythmias 3) CNS- dyskinesia, chorea, ballismus, myuclonus, tics, tremors 4) behavoral- anxiety, agitation, hallucinations, delusions, depression |
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Bromocriptine toxicity |
Ergot poisoning Erythromelagia, pulmonary infiltrates |
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Amantadine |
Improves bradykinesia, rigidity, and tremor Toxicity- restlessmess, agitation, insomnia, hallucination, confusion, acute toxic psycosis Livedo reticularis GI disturbances, urinary retention, postural hypotension, peripheral edema |
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Levodopa |
×bradykinesia Does not cure parkinsonism Response dec with time On and off phenomenon Drug holidays |
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Pramipexole |
Non ergot D3 AE- anorexia, vomiting, nausea, postural hypotension, dykinesia Confusion, delusions, hallucinations, tendency to sleep |
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Drug induced parkinsonism |
1) antipsycotic drugs- dopa receptors 2) reserpine- dec dopamine 3) MPTP- destruction of dopaminergic neurons- irreversible parkinsonism |
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Types of parkinsonism |
1) naturally occuring 2) Drug induced |
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Pramipexole CA |
Pepetic ulcer disease Psycotic illness Myocardial infarction |
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Ropinirole |
Non ergot D2 Metabolized by CYP1A2 Caffein, warfarin reduce clearance |
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Bromocriptine |
Ergot D2 receptor |
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Apomorphine |
Rapid Temporary relief 1-2h of off periods Severe nausea AE- dyskinesia, hypotension, drowsiness and sweating |
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Pramipexole feature |
Neuroprotective Scavenger for hydrogen peroxide |
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Levodpa CA |
Psycosis |
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MAO I |
Hepatic metatolism of selegiline- desmethylselegiline (neuroprotective) & amphetamine AE- insomnia, mood changes, dykinesia, gI distress, hypotension Serotinin syndrome |
