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14 Cards in this Set
- Front
- Back
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Insulinogouges
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Osu
Repaglinide Exenatide Sitagliptin |
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OSU MoA:
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K+ channel blocker= Membrane depolarization= calcium influx= insulin release
INCREASES INSULIN RECEPTOR SENSITIVITY |
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Acetohexamide Usage
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Decrease dose in renal dysfunction
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Glipizide
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Decrease dose in hepatic dysfunction
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Glyburide
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Decrease dose in renal dysfunction
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OSU SE:
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Early morning hypoglycemia( 2-3 AM)
Weight gain Drug Interaction-Increased Hypoglycemia with cimetidine, insulin, salicylates and sulphonamides-All protein bound |
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Metformin MoA
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Increased tissue sensitivity to insulin and decreased hepatic gluconeogenesis
synergistic with OSU's |
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Miglitol
Acarbose MoA and SE |
Inhibits a-glucosidase in brush borders of small intestine=decreased glucose absorption
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Miglitol
Acarbose SE |
No hypoglycemia, Heptatotoxicity, flatulence. diarrhea
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Pioglitazone and Rosiglitazone MoA and SE
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Activates peroxisome proliferator- activating receptors, increases insulin sensitivity and decreases hepatic gluconeogenesis
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Exenatide MoA
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GLP-1 Receptor agonist(insulinogogue)
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Sitagliptin MoA
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Inhibits dipeptidyl peptidase-4 thereby inhibiting inactivation of GLP-1( Insulinogogue)
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Pramlintide MoA
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Synthetic version of amylin slows down the rate at which food is absorbed from the intestine, decreses apetite
Used in DM T1 and T2 |
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Minoxidil and Diazoxite MoA
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Open ATP dependent K+ Channels MoA opposite of OSU's
Decreases insulin release |
