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20 Cards in this Set
- Front
- Back
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d-Tubocurarine
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•Class: Non-polarizing Neuromuscular Blocker
•Receptor: Nm •Action: slow onset, long duration; competitive antagonist at NMJ and prejuntional Na channel; causes histamine release; can be overcome with inc. ACh; ionized (no CNS entry) •Indications: paralysis of skeletal mm. •SE/CI: ganglionic blockade, vagal blockade |
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Pancuronium (Pavulon)
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•Class: Non-polarizing Neuromuscular Blocker
•Receptor: Nm •Action: slow onset, long duration •Indications: •SE/CI: moderate block of N and M, vagal blockage, tachycardia |
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Vecuronium (Norcuron)
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•Class: Non-depolarizing Neuromuscular Blocker
•Receptor: Nm •Action: slow onset, intermediate duration •Indications: •SE/CI: |
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Cisatracurium (Nimbex)
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•Class: Non-polarizing Neuromuscular Blocker
•Receptor: Nm •Action: most commonly used; no histamine release •Indications: •SE/CI: |
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Rocuronium (Zemuron)
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•Class: Non-polarizing Neuromuscular Blocker
•Receptor: Nm •Action: rapid onset, intermediate duration •Indications: Intubation •SE/CI: |
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Succinylcholine (Anectine)
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•Class: Depolarizing Neuromuscular Blocker
•Receptor: Nm •Action: rapid onset and duration; initial stimulation and contraction but receptor desensitized causing paralysis; hydrolyzed by plasma pseudocholinesterase •Indications: intubation, ventilation; Sx; convulsions; Ca channel blockage •SE/CI: CI- bruns, severe trauma, nn. degeneration, CNS injury (causes release of K+ into blood leading to cardiac arrest) |
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Mecamylamine (Inversine)
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•Class: Ganglion blocker
•Receptor: •Action: non-depolarizing competitive antagonist; blocks ALL autonomic ganglia •Indications: used to treat HTN •SE/CI: effects similar to blocking both SNS and PNS; decreases autonomic reflexes |
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Hexamethonium
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•Class: Ganglion blocker
•Receptor: •Action: decreases autonomic reflexes •Indications: Tourette's, nicotine/cocaine addiction •SE/CI: |
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Epinephrine (Adrenalin)
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•Class: Catecholamine
•Receptor: Alpha, Beta-1, Beta-2 •Action: short duration; dose dependent ••LOW- +ionotropic, chronotopic; increase in systolic and diastolic pressures followed by dec in D BP due to vasodilation of bv's; little overall change in BP but inc HR ••HIGH- more alpha; pressor effect; D and S BP increase while there is less inc HR; inc in blood glucose and renin •Indications: anaphylactic shock; cardiac arrest; complete heart block •SE/CI: CI- beta blocker use (severe alpha increase, severe HTN) |
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Norepinephrine (Levophed)
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•Class: Catecholamine
•Receptor: Alpha, Beta-1 •Action: vasoconstriction to increase BP with reflex bradycardia •Indications: severe hypotension •SE/CI: |
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Isoproterenol (Isuprel)
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•Class: Catecholamine
•Receptor: Beta-1, Beta-2 •Action: +ionotrope, chronotrope; vasodilation in skeletal mm. leading to dec BP with reflex tachycardia •Indications: cardiac arrest, complete heart block •SE/CI: large doses cause tachycardia, palpitations, arrhythmias |
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Dopamine (Intopin)
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•Class: Catecholamine, DA agonist
•Receptor: Beta-2, D1 •Action: dose dependent: ••LOW- activate D1 in renal vascular beds, vasodilation ••HIGH- stimulate beta-1 in heart (+inotrope, chronotrope) ••OD- release NE to stimulate alpha-1, vasoconstriction, inc BP •Indications: IV tx for cardiac shock •SE/CI: N/V; tachycardia, angina, arrythmias; HA, peripheral vasoconstriction CI- pheochromocytoma, MAOIs |
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Phenylephrine (Neo-Synephrine)
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•Class: Alpha-1 agonist
•Receptor: Alpha-1 •Action: vasoconstriction, inc BP with slight reflex bradycardia; mydriasis without cycloplegia •Indications: decongestant; hypotensive emergency to increase BP •SE/CI:ischemic changes with chronic use; CI- HTN |
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Pseudoephrine (Sudafed)
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•Class: Alpha agonist
•Receptor: •Action: less tachy and CNS effects •Indications: OTS decongestant •SE/CI: HTN caution |
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Clonidine (Catapres)
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•Class: Alpha-2 agonist
•Receptor: Alpha-2 •Action: acts presynaptically in CNS to decrease NE release; decrease in BP, HR •Indications: HTN •SE/CI: HTN may occur with fast withdrawal |
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Apraclonidine (Iopidine)
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•Class: Alpha-2 agonist
•Receptor: Alpha-2 •Action: dec intraocular pressure •Indications: Open angle glaucoma •SE/CI: |
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Dobutamine (Dobutrex)
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•Class: Beta-1 agonist
•Receptor: Beta-1 •Action: +ionotropic, chronotropic; increased cardiac output with little effect on peripheral resistance •Indications: cardiac stress test; increase cardiac output for cardiogenic shock and CHF •SE/CI: HTN caution |
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Albuterol (Ventolin), Terbutaline (Brethine)
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•Class: Beta-2 Agonist
•Receptor: Beta-2 •Action: small effect on beta-1 •Indications: inhalation asthma tx •SE/CI: HA, tremors, tachy |
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Ritrodine (Yutopar)
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•Class: Beta-2 agonist
•Receptor: Beta-2 •Action: small effect on beta-1 •Indications: relax uterus and suppress pre-term labor •SE/CI: |
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Ephedrine
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•Class:N/A
•Receptor: Alpha •Action: long duration; similar to Epi but less prounounced; CNS stimulant •Indications: •SE/CI: herbal that was taken off market due to severe HTN and hemorrhagic stroke |
