Drugs Lecture 1

Front 1

Amlodipine

List 1

Back 1

Allosteric ion channel modulator; Calcium channel blocker. Reducing influx of calcium allowing for SM relaxation an increase in coronary blood flow and therefore greater perfusion to myocardium

Front 2

Lidocaine

List 2

Back 2

a local anaesthetic, as an example of an ion channel blocker and a non-competitive antagonist, at Na+ channels

Front 3

Diazepam

List 2

Back 3

As a facilitatory ion channel modulator (GABAA receptor-operated chloride channel), anxiolytic properties. Allows Cl- entry and hyperpolarsations uses in insomnia and neurology

Front 4

Furosemide

List 1

Back 4

NKCC blocker in renal tubular cells as a diuretic

Front 5

Lisinopril

List 1

Back 5

Inhibitor of angiotensin converting enzyme (ACE) as an example of an enzyme inhibitor

Front 6

Perindopril

List 1

Back 6

An example of a pro-drug which requires conversion by enzymes in the liver to the active metabolite perinodoprilat which is an inhibitor of the enzyme ACE

Front 7

Infliximab

List 2

Back 7

as an example of a drug which is an antibody to a protein mediator (cytokine), will be covered in the pharmacology of inflammation and

Front 8

Cisplantin

List 2

Back 8

As an example of a drug interacting with nucleic acids as a molecular target, will be covered in cancer chemotherapy lectures later in your

Front 9

Amoxicillin

List 2

Back 9

Prevent peptidoglycan cross link of polymer chains ..as an example of a drug acting on micro-organisms (i.e. not part of human cells or tissues); amoxicillin is a penicillin-type antibiotic and inhibits formation of bacterial cell walls