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11 Cards in this Set
- Front
- Back
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Renin-angiotensin system |
1) Circulating renin-angiotensin system 2) Local/tissue renin angiotensin system |
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ACE in Circulating renin-angiotensin system |
Located on luminal surface of vascular endothelial cells (especially in lungs) |
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Mesangial cells |
1) mesangial cells /intraglomerular mesangial cells 2) lacis cells/extraglomerular mesangial cells |
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Juxtraglomerular apparatus |
1) macula densa cells- epithelial cells of thick ascending limb of LH 2) juxtraglomerular cells- modified smooth muscle cells present in the tunica media of afferent arteriole, Secrets Renin 3) lacis cells- located in triangle bounded by macula densa, afferent & efferent arteriole |
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Renin-angiotensin system and sites of action of its inhibitors |
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Location of Angiotensin Receptors |
AT1- vascular smooth muscle, myocardium, plasma membrane of target cells AT2- Foetas: widely distributed in all tissue s Adult: Adrenal medulla, vascular endothelium & in some parts of brain |
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Inhibitors of renin-angiotensin system |
1) Renin release inhibitors - Beta blockers
2) Direct renin inhibitors - Aliskiren
3) ACE inhibitors - Captopril, enalapril, lisinopril, benzepril, ramipril, perindopril
4) Angiotensin receptor blockers/ARB- Losartan, candesartan, valsartan, telmisartan, irbesartan |
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Kallikrein-Kinin System |
Kininogens ———>kinins *by the action of enzyme Kallikrein Important kinins - > Bradykinin & kallidin |
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Regulation of Kallikrein-Kinin System |
Kininase II is identical to ACE |
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Kinin receptors |
B1 & B2 (B is not beta) |
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Actions of Kinins |
Dialates arterioles Increase capillary permeability Slow contraction of smooth muscle mainly intestine, uterus & bronchi Stimulates sensory nerve endings Note: ACE /kininase II inactivates Vasodilator (bradykinin) and activates vasoconstrictor (angiotensin II) |
