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17 Cards in this Set
- Front
- Back
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How do people die from CVD? |
Coronary heart disease (CHD) Stroke Heart failure (HF) |
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Whats the major risk factor CHD,stoke ,HF |
Artherosclerosis Hypertension |
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Whats the key risk factor in the development of atherosclerosis? |
HYpercholesterolemia |
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What is atherosclerosis? |
Deposit of plaques containing containing cholesterol and lipids on the innermost layer of the walls of arteries . |
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What are the classes of Hypolipidemic Drugs |
Statins Fibrates Bile acid binding resins Ezetimibe Niacin |
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Statins act as |
Competitive inhibitor of hydroxymethylglutaryl Co A reducatase Structural analogues of 3-hydroxy 3- methylglutaryl Co A |
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What's the mechanism of action of statins |
Block cholesterol synthesis in the liver (act as competitive enzyme inhibitor) Promotes increased expression of LDL (low density lipoprotein) receptor which will increase the clearance, |
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What's the mechanism of action of fibrates |
Agonists at PPAR alpha receptor |
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Whats the effects of fibrates |
Promote lipolysis of triglyceride in chylomicron and VLDL via lypoprotein lipase (LPL) Decreased hepatic VLDL production and increase hepatic LDL uptake |
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What is bile acid binding resins? |
Non-absorbable drugs |
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Whats the mechanism of bile acid binding resins? |
Bind to bile salts in the intestine and prevent the reabsorption and enterohepatic recirculation |
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Whats the side effects if BABR |
GIT disturbance Nausea Constipation Interfere with the absorption of fat soluble vitamins. |
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What is Ezetimibe ? |
Selective inhibitor of intestinal absorption of cholesterol |
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Whats the mechanism of Ezetimibe? |
Blocking a transport protein (NPC1L1) in the brush border of enterocytes |
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Does ezetimibe affect the absorption of fat soluble vitamins ,tgl or bile acids? |
No |
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What does ezetimibe inhibit? |
Ezetimibe inhibit reabsorption of cholesterol excreted in the bile Effective even in the absence of dietary cholesterol |
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Drugs used to treat hypertension |
Angiotension converting enzyme (ACE) inhibitors and angiotensin receptor antagonists (ARBs) BETA blockers
Diuretics |
