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8 Cards in this Set
- Front
- Back
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What drugs was widely used in the past as a folk medicine, and is usually derived from plants? |
Cocaine |
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Cocaine in the 19th century? |
Uncontrolled Available from grocery stores Mechanisms not understood- ant therefore not the side effects Included in patent medicines |
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What effect of cocaine were Bier and Hildebrand interested in (1898) ? |
Local anaesthetic |
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How did Bier and Hildebrand study effects of cocaine? |
Wanted to look at studies on spinal cord Injected cocaine into spine was self-testing on one another Showed general anaesthetic effects on spinal cord |
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Derivatives of cocaine: When were they made? Benefits if any? |
Early 1900's cocaine was regulated as a drug 1905:- Procaine Wanted local anaesthetic without euphoria, meant little chance of addiction 1943: Lidocaine Still used today, over 70 years later |
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Who is father of modern drug discovery? First example of synthetic drug discovery and production? |
Paul Ehrilich: 1854-1915 research into sleeping sickness 900+ Arsenic based compounds tested on animal models later: Compound #606 tested on syphilis:- Completely effective Drug released in 1910 as Salvarsan Salvarsan was the only treatment until antibiotics Syphillis big problem in victorian times First example of systematic drug production |
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Pharmacodynamics? |
Mechanisms of how a drug works |
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Pharmacokinetics? |
Bodies handling of a drug |
