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What drugs was widely used in the past as a folk medicine, and is usually derived from plants?
Cocaine
Cocaine in the 19th century?
Uncontrolled
Available from grocery stores
Mechanisms not understood- ant therefore not the side effects
Included in patent medicines
What effect of cocaine were Bier and Hildebrand interested in (1898) ?
Local anaesthetic
How did Bier and Hildebrand study effects of cocaine?
Wanted to look at studies on spinal cord
Injected cocaine into spine
was self-testing on one another
Showed general anaesthetic effects on spinal cord
Derivatives of cocaine:
When were they made?
Benefits if any?
Early 1900's cocaine was regulated as a drug
1905:- Procaine
Wanted local anaesthetic without euphoria, meant little chance of addiction
1943: Lidocaine
Still used today, over 70 years later
Who is father of modern drug discovery?
First example of synthetic drug discovery and production?
Paul Ehrilich: 1854-1915
research into sleeping sickness
900+ Arsenic based compounds tested on animal models
later: Compound #606 tested on syphilis:- Completely effective
Drug released in 1910 as Salvarsan
Salvarsan was the only treatment until antibiotics
Syphillis big problem in victorian times
First example of systematic drug production
Pharmacodynamics?
Mechanisms of how a drug works
Pharmacokinetics?
Bodies handling of a drug
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