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13 Cards in this Set
- Front
- Back
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Single base alterations |
Deamination of cytosine to uracil, depurination, Deamination of adenine to hypoxanthine, Base-analog incorporation, Alkylation of base |
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Two base alterations |
UV light on thymine to thymine dimer, Bifunctional alkylating agent cross-linkage |
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Chain breaks |
Ionizing radiation, radioactive disintegration of backbone element, oxidative free radical |
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Cross-linkage |
Between bases in same or opposite strands, Between DNA & protein molecules |
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DNA repair mechanisms |
Nucleotide excision repair, Mismatch repair, Base excision repair, Homologous recombination, Non-homologous end joining |
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Xeroderma pigmentation |
Nucleotide-excision repair |
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Cockayne syndrome |
Transcription - coupled repair, nucleotide - excision repaor |
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Trichothiodystrophy |
Nucleotide - excision repair |
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Hereditary nonpolyposis colon cancer (HNPCC) |
Mismatch repair |
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Fanconi anemia |
Interstrand crosslinks repair |
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Ataxia telangiectasia |
DNA damage detection and response |
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Li-Fraumeni syndrome |
DNA damage response |
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Breast, ovarian and colon cancer |
Homologous recombination, BRCA2 |
