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37 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name 5 SNRIs
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Venlafaxine
Desvenlafaxine Duloxetine Milnacipran Nefazodone * MoA? * Tx? |
Inhibits reuptake of serotonin & norepinephrine
Tx: depression Venlafaxine: GAD Duloxetine: diabetic peripheral neuropathy |
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Name 3 SSRIs
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Citalopram
Paroxetine Sertraline * MoA? * Tx? |
Specifically inhibits serotonin reuptake
Tx: depression, OCD, bulimia, social phobias |
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Name 6 TCAs
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Nortriptyline
Imipramine Chlomipramine Despiramine Doxepin * MoA? * Tx? * Toxicity? |
MoA: blocks reuptake of NE & 5-HT
Tx: major depression, bed wetting OCD, fibromyalgia Toxicity: Tri-C's (Convulsions, Coma, Cardiotoxicity) |
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Name 3 MAO Inhibitors
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Selegiline (MAO-B specific)
Phenelzine Tranlycypromine * MoA? * Tx? * Toxicity? |
MoA: non-selective MAO inhibition → ↑ amine NTs
Tx: atypical depression, anxiety Toxicity: hypertensive crisis with tyramine ingestion C/I: with SSRI's or Meperidine (prevent serotonin syndrome) |
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Buproprion MoA?
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↑ NE & Dopamine uptake
* Tx? * Preferred b/c? |
Tx: depression, smoking cessation
* works well with SSRIs Preferred b/c no sexual side effects |
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Tetracyclic antidepressants?
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Trazodone
Mitrazapine * MoA? |
Trazodone: inhibits 5-HT reuptake; used for insomnia; causes priapsm
Mitrazapine: α2 antagonist → ↑ NE & 5-HT release; |
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How does the drug dose response curve change with addition of competitive vs. non-competitive antagonist?
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Competitive: ↓ potency (↑ Km)
Non-comp: ↓ efficacy (↓ Vmax) |
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HY: worst headache of my life
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Subarachnoid hemorrhage
* MC predisposing lesion? * MC site? |
Berry aneurysm
Anterior Communicating Artery |
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HY: waxy casts in urine
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Chronic Renal Failure/End Stage
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HY: neuropathy + AV nodal block
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Stage II Lyme Disease
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HY: port-wine stain in V1 division
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Sturge-Webber Syndrome
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HY: urethritis, conjunctivitis, arthritis
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Reiter's
* Association with HLA? * Other associations? |
HLA- B27
"PAIR" Psoriasis/arthritis Ankylosing Spondylitis IBD (Crohn's) Reiter's (Reactive Arthritis) |
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HY: lack of GpIIb/IIa
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Glanzmann Thrombasthenia
* Pathophysio? |
Defect in platelet aggregation →
mucosal bleeding & ↑ bleeding time |
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HY: painless jaundice
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Pancreatic cancer (head)
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Nerve most at risk for injury with following injury/fracture:
medial epicondyle |
Ulnar nerve
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Nerve most at risk for injury with following injury/fracture:
anterior shoulder dislocation |
Axillary n.
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Nerve most at risk for injury with following injury/fracture:
shaft of the humerus |
Radial n.
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Nerve most at risk for injury with following injury/fracture:
surgical neck of humerus |
Axillary n.
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Nerve most at risk for injury with following injury/fracture:
supracondyle of humerus |
Median n.
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Nerve most at risk for injury with following injury/fracture:
carpal tunnel |
Median n.
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Name the phagocyte immunodeficiencies
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CGD
Job's (Hyper IgE) Leukocyte Adhesion Chédiak–Higashi |
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Name X-linked immunodeficiencies
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Bruton's agammaglobulinemia
Hyper IgM SCID (MC;defective IL-2 receptor) Wiskott-Aldrich |
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Cell surface marker: CD4
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T-cell
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Cell surface marker: CD14
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Macrophage
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Cell surface marker: CD16
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Natural killer & Macrophage
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Cell surface marker: CD19
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B-cell
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Cell surface marker: CD3
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T-cell
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Cell surface marker: CD8
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T-cell (cytotoxic T-cell)
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Personality disorder:
need to be taken care of, clingy, submissive, low self-confidence, fear of separation & losing support |
Dependent
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Personality disorder:
suicide attempts, unstable modd/behavior, sense of emptiness/loneliness, impulsiveness |
Borderline
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Personality disorder:
grandiosity, feels entitled, lack of empathy |
Narcissistic
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Personality disorder:
odd appearance, thoughts, & behavior, social awkwardness |
Schizotypal
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Personality disorder:
controlling, perfectionistic, orderly, stubborn, indecisive |
Obsessive-Compulsive
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Personality disorder:
criminality, unable to conform to social norms, disregard for others' rights |
Anti-social
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Distinguishing feature:
Autism |
Low intelligence
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Distinguishing feature (s):
Rett disorder |
Girls
Autosomal Dominant Hand-wringing Small head circumference |
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Distinguishing feature(s):
Asperger |
Normal intelligence
Poor social skills |
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