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37 Cards in this Set

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Name 5 SNRIs
Venlafaxine
Desvenlafaxine
Duloxetine
Milnacipran
Nefazodone

* MoA?
* Tx?
Inhibits reuptake of serotonin & norepinephrine

Tx: depression
Venlafaxine: GAD
Duloxetine: diabetic peripheral neuropathy
Name 3 SSRIs
Citalopram
Paroxetine
Sertraline

* MoA?
* Tx?
Specifically inhibits serotonin reuptake

Tx: depression, OCD, bulimia, social phobias
Name 6 TCAs
Nortriptyline
Imipramine
Chlomipramine
Despiramine
Doxepin

* MoA?
* Tx?
* Toxicity?
MoA: blocks reuptake of NE & 5-HT

Tx: major depression, bed wetting OCD, fibromyalgia

Toxicity: Tri-C's (Convulsions, Coma, Cardiotoxicity)
Name 3 MAO Inhibitors
Selegiline (MAO-B specific)
Phenelzine
Tranlycypromine

* MoA?
* Tx?
* Toxicity?
MoA: non-selective MAO inhibition → ↑ amine NTs

Tx: atypical depression, anxiety

Toxicity: hypertensive crisis with tyramine ingestion

C/I: with SSRI's or Meperidine (prevent serotonin syndrome)
Buproprion MoA?
↑ NE & Dopamine uptake

* Tx?
* Preferred b/c?
Tx: depression, smoking cessation
* works well with SSRIs

Preferred b/c no sexual side effects
Tetracyclic antidepressants?
Trazodone
Mitrazapine

* MoA?
Trazodone: inhibits 5-HT reuptake; used for insomnia; causes priapsm

Mitrazapine: α2 antagonist → ↑ NE & 5-HT release;
How does the drug dose response curve change with addition of competitive vs. non-competitive antagonist?
Competitive: ↓ potency (↑ Km)

Non-comp: ↓ efficacy (↓ Vmax)
HY: worst headache of my life
Subarachnoid hemorrhage

* MC predisposing lesion?
* MC site?
Berry aneurysm

Anterior Communicating Artery
HY: waxy casts in urine
Chronic Renal Failure/End Stage
HY: neuropathy + AV nodal block
Stage II Lyme Disease
HY: port-wine stain in V1 division
Sturge-Webber Syndrome
HY: urethritis, conjunctivitis, arthritis
Reiter's

* Association with HLA?
* Other associations?
HLA- B27

"PAIR"
Psoriasis/arthritis
Ankylosing Spondylitis
IBD (Crohn's)
Reiter's (Reactive Arthritis)
HY: lack of GpIIb/IIa
Glanzmann Thrombasthenia

* Pathophysio?
Defect in platelet aggregation →
mucosal bleeding & ↑ bleeding time
HY: painless jaundice
Pancreatic cancer (head)
Nerve most at risk for injury with following injury/fracture:
medial epicondyle
Ulnar nerve
Nerve most at risk for injury with following injury/fracture:
anterior shoulder dislocation
Axillary n.
Nerve most at risk for injury with following injury/fracture:
shaft of the humerus
Radial n.
Nerve most at risk for injury with following injury/fracture:
surgical neck of humerus
Axillary n.
Nerve most at risk for injury with following injury/fracture:
supracondyle of humerus
Median n.
Nerve most at risk for injury with following injury/fracture:
carpal tunnel
Median n.
Name the phagocyte immunodeficiencies
CGD
Job's (Hyper IgE)
Leukocyte Adhesion
Chédiak–Higashi
Name X-linked immunodeficiencies
Bruton's agammaglobulinemia
Hyper IgM
SCID (MC;defective IL-2 receptor)
Wiskott-Aldrich
Cell surface marker: CD4
T-cell
Cell surface marker: CD14
Macrophage
Cell surface marker: CD16
Natural killer & Macrophage
Cell surface marker: CD19
B-cell
Cell surface marker: CD3
T-cell
Cell surface marker: CD8
T-cell (cytotoxic T-cell)
Personality disorder:
need to be taken care of, clingy, submissive, low self-confidence, fear of separation & losing support
Dependent
Personality disorder:
suicide attempts, unstable modd/behavior, sense of emptiness/loneliness, impulsiveness
Borderline
Personality disorder:
grandiosity, feels entitled, lack of empathy
Narcissistic
Personality disorder:
odd appearance, thoughts, & behavior, social awkwardness
Schizotypal
Personality disorder:
controlling, perfectionistic, orderly, stubborn, indecisive
Obsessive-Compulsive
Personality disorder:
criminality, unable to conform to social norms, disregard for others' rights
Anti-social
Distinguishing feature:
Autism
Low intelligence
Distinguishing feature (s):
Rett disorder
Girls
Autosomal Dominant
Hand-wringing
Small head circumference
Distinguishing feature(s):
Asperger
Normal intelligence
Poor social skills