Dit Day 1 - Autonomic Drugs

Front 1

Bethanecol

Back 1

Category: Direct Cholinergic agonist.
Application: postop ileus and urinary retention.
Action: Give beth anne a call to move bladder and bowel.

Front 2

Carbachol

Back 2

Category: Direct Cholinergic Agonist
Application: Glaucoma, pupillary contraction, relieves intraocular pressure.
Action: carbon copy of ACh

Front 3

Pilocarpine

Back 3

Category: Direct Cholinergic agonist
Application: stimulates sweat, tears, saliva
Action: contracts ciliary muscle and pupillary sphincter. Pile on sweat and tears.

Front 4

Methacholine

Back 4

Category: direct cholingergic agonist
Application: Challenge test to diagnose asthma.
Action: stimulates muscarinic receptors in airway.

Front 5

Neostigmine

Back 5

Category: ACh-E inhibitor
Application: Post op ileus, urinary retention, MG, reversal of NMJ block
Action: inc endogenous ACh, no (NEO) CNS penetration

Front 6

Pyridostigmine

Back 6

Category: AChE inhibitor
Application: MG
Action: increases endogenous ACh, strength

Front 7

Edrophonium

Back 7

Category: AChE inhibitor
Application: Diagnose MG
Action: short acting, increases endogenous ACh

Front 8

Physostigmine

Back 8

Category: AChE inhibitor
Application: Glaucoma and atropine OD (crosses CNS)
Action: inc endogenous ACh, Phys for the Eyes

Front 9

Echothiophate

Back 9

Category: AChE inhibitor
Application: glaucoma
Action: incr endogenous ACh

Front 10

Atropine

Back 10

Category: muscarinic antagonist
Application: mydriasis and cycloplegia in eye
Toxicity: DUMBBELSS

Front 11

Homatropine

Back 11

Category: muscarinic antagonist
Atropine analog

Front 12

Tropicamide

Back 12

Category: muscarinic antagonist
Atropine analog

Front 13

Benztropine

Back 13

Category: muscarinic antagonist
Organ: CNS
Application: Parkinson's
Action: blocks action of ACh in CNS

Front 14

Scopolamine

Back 14

Category: muscarinic antagonist
Organ: CNS
Application: motion sickness

Front 15

Ipratropium

Back 15

Category: muscarinic antagonist
Organ: Respiratory
Application: Asthma and COPD
Ipra - I pray I can breathe soon

Front 16

Oxybutynin

Back 16

Category: muscarinic antagonist
Organ: GU
Application: reduce urinary urgency

Front 17

Glycopyrrolate

Back 17

Category: muscarinic antagonist
Organ: GU
Application: reduce urinary urgency

Front 18

Methscopalamine

Back 18

Category: muscarinic antagonist
Organ: GI
Application PUD

Front 19

Propantheline

Back 19

Category: muscarinic antagonist
Organ: GI
Application: PUD

Front 20

Hexamethonium

Back 20

Category: nicotinic antagonist (works at ganglion)
Application: experimentally blocks reflex responses to changes in BP. Has the effect of decreasing the main autonomic innervation's response (usually anti-parasympathetic)

Front 21

Epinephrine

Back 21

Category: Direct sympathomimetic
Selectivity: a1, a2, B1, B2
Applications: anaphylaxis

Front 22

Norepinephrine

Back 22

Category: Direct sympathomimetic.
Selectivity: a1, a2, B1
Application: Septic Shock

Front 23

Isoproterenol

Back 23

Category: Direct sympathomimetic
Selectivity: B1 = B2 (ISOlated to B)
Application: AV block (rarely)

Front 24

Dopamine

Back 24

Category: Direct sympathomimetic
Selectivity: D1 = D2 > B > a
Application: increases renal perfusion

Front 25

Dobutamine

Back 25

Category: Direct sympathomimetic
Selectivity: B1>B2
Action: Inotropic and chronotropic
Application: heart failure, stress test

Front 26

Phenylephrine

Back 26

Category: Direct sympathomimetic
Selectivity: a1 > a2
Use: pupillary dilation, vasoconstriction, nasal decongestion, stop nosebleed.

Front 27

Metaproterenol

Back 27

Category: Direct sympathomimetic
Selectivity: B2
Use: acute asthma

Front 28

Albuterol

Back 28

Category: Direct sympathomimetic
Selectivity: B2>B1
Use: acute asthma

Front 29

Salmeterol

Back 29

Category: Direct sympathomimetic
Selevtivity: B2>B1
Use: long term asthma tx

Front 30

Terbutaline

Back 30

Category: Direct sympathomimetic
Selecticity: B2>B1
Use: reduces premature uterine contraction

Front 31

Ritodrine

Back 31

Category: Direct sympathomimetic
Selectivity: B2
Use: premature uterine contraction

Front 32

Aphetamine

Back 32

Category: Indirect sympathomimetic
Action: releases stored catecholamines
Use: narcolepsy, ADHD, obesity, major depressive disorder while waiting for another drug to kick in

Front 33

Tyramine

Back 33

Category: Indirect sympathomimetic
Action: releases stored cathecholamines, doesn't cross BBB
Found in cheese, can increase BP in people on MAO-I's

Front 34

Ephedrine

Back 34

Category: Indirect sympathomimetic
Action: release stored catecholamines.
Use: nasal decongestion, urinary incontinence, hypotension

Front 35

Cocaine

Back 35

Category: Indirect sympathomimetic
Action: catecholamine uptake inhibitor
Use: local anesthesia, vasoconstriction (esp in ENT work)

Front 36

Clonidine

Back 36

central acting a2 agonist.
decreases central adrenergic outflow

Front 37

Phenoxybenzamine

Back 37

Category: a-blocker
Action: irreversible alpha blocker.
Use: pheochromocytoma
Tox: orthostatic hypotension, refle tachy

Front 38

Phentolamine

Back 38

Category: a-blocker
Action: reversible
Use: pheochromocytoma

Front 39

Prazosin

Back 39

Category: a-blocker
Action: selective a1 blocker
Use: HTN, urine retention in BPH
Tox: 1st dose syncope

Front 40

terazosin

Back 40

Category: a-blocker
Action: selective a1 blocker
Use: HTN, urine retention in BPH
Tox: 1st dose syncope

Front 41

Doxazosin

Back 41

Category: a-blocker
Action: selective a1 blocker
Use: HTN, urine retention in BPH
Tox: 1st dose syncope

Front 42

Mirtazapine

Back 42

Category: a-blocker
Action: a2 selective
Use: depression
Tox: increased appetite, sedation, inc cholesterol (take advantage of side effects)

Front 43

Acebutolol

Back 43

Category: B-blockers
Selectivity: B1 (good with concurrent pulm disease - no bronchospasm)
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, sedation, CV AE

Front 44

Betaxolol

Back 44

Category: B-blockers
Selectivity: B1(good with concurrent pulm disease - no bronchospasm)
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, sedation, CV AE

Front 45

Esmolol

Back 45

Category: B-blockers
Selectivity: B1 (good with concurrent pulm disease - no bronchospasm)
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, sedation, CV AE

Front 46

Atenolol

Back 46

Category: B-blockers
Selectivity: B1 (good with concurrent pulm disease - no bronchospasm)
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, sedation, CV AE

Front 47

Metoprolol

Back 47

Category: B-blockers
Selectivity: B1 (good with concurrent pulm disease - no bronchospasm)
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, sedation, CV AE

Front 48

Propanolol

Back 48

Category: B-blockers
Selectivity: B1 = B2
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, asthma, sedation, CV AE

Front 49

Timolol

Back 49

Category: B-blockers
Selectivity: B1 = B2
Use: Glaucoma

Front 50

Pindolol

Back 50

Category: B-blockers
Selectivity: B1 = B2
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, asthma, sedation, CV AE

Front 51

Labetolol

Back 51

Category: B-blockers
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, asthma, sedation, CV AE

Front 52

Nadolol

Back 52

Category: B-blockers
Selectivity: B1 = B2
Use: HTN, Angina, MI, chronic CHF,
Tox: ED, asthma, sedation, CV AE