Diseases Of The Skin

Front 1

circumscribed lesion of < 5mm in diameter characterized by flatness and usually distinguished from surrounding skin by its coloration

Back 1

Macule

Front 2

circumscribed lesion of > 5mm in diameter characterized by flatness and usually distinguished from surrounding skin by its coloration

Back 2

Patch

Front 3

elevated dome-shaped or flat-topped lesion < 5mm in diameter

Back 3

Papule

Front 4

elevated lesion with spherical contour > 5mm in diameter

Back 4

nodule

Front 5

: elevated flat-topped lesion,usually > 5mm in in diameter

Back 5

Plaque

Front 6

fluid filled raised lesion < 5mm in diameter

Back 6

Vesicle

Front 7

fluid filled raised lesion > 5mm in diameter

Back 7

Bulla / Blister

Front 8

discrete, pus-filled, raised lesion

Back 8

Pustule

Front 9

itchy, transient, elevated lesion with variable blanching and erythema formed as the result of dermal edema

Back 9

Wheal

Front 10

dry, horny, platelike excresence, usually the result of imperfect cornification

Back 10

Scale

Front 11

thickened and rough skin characterized by prominent skin markings; can be the result of repeated rubbing

Back 11

Lichenification

Front 12

traumatic lesion characterized by breakage of the epidermis causing a raw linear area; often self-induced

Back 12

Excoriation

Front 13

separation of the nail plate from the nail bed

Back 13

Oncholysis

Front 14

thickening of the stratum corneum, often associated with a qualitative abnormality of the keratin

Back 14

Hyperkeratosis

Front 15

diffuse epidermal hyperplasia

Back 15

Acanthosis

Front 16

surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae

Back 16

Papillomatosis

Front 17

abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum

Back 17

Dyskeratosis

Front 18

loss of intercellular connections resulting in loss of cohesion between keratinocytes.

Back 18

Acantholysis

Front 19

intercellular edema of the epidermis

Back 19

Spongiosis

Front 20

infiltration of the epidermis by inflammatory or circulationg blood cells

Back 20

Exocytosis

Front 21

infiltration of the epidermis by inflammatory or circulationg blood cells

Back 21

Erosion

Front 22

discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat

Back 22

Ulceration

Front 23

a linear pattern of melanocyte proliferation within the epidermal basal cell layer

Back 23

Lentiginous

Front 24

-Symmetric
-Well-defined, rounded border
-Uniformly pigmented
-Small (usually <6 mm across)
-No increase in size
are general characteristics of?

Back 24

Nevocellular Nevus

Front 25

What are the 3 classifications of Nevocellular Nevus?

Back 25

1) junctional (macule)
2) dermal (nodule/papule)
3) compound (nodule/papule)

Front 26

a benign neoplasm of melanocytes that may be acquired or congenital

Back 26

Nevocellular Nevus

Front 27

What is a malignant neoplasm of melanocytes that in skin, begins as a macule and may become a patch or papule?

Back 27

Melanoma

Front 28

What are precursor lesion(s) to a Melanoma that may be seen?

Back 28

Dysplastic Nevi and congenital melanocytic nevi

Front 29

What some risk factors for acquiring a melanoma?

Back 29

- family history
- skin type
- excessive sun exposure
-precursor lesions (dysplastic nevi)

Front 30

What type of nevi have the highest risk of developing into melanomas?

Back 30

-large or giant types (6%)
-3-5 yo

Front 31

6th most common cancer in US?

Back 31

Melanoma

Front 32

most common fatal malignancy amongst young adults?

Back 32

Melanoma

Front 33

Prognosis of a melanoma is based upon?

Back 33

1) Thickness of tumor
2) presence/absence of ulceration
3) clinical stage

Front 34

-warty surface
-waxy, tan/brown plaque
-solitary/multiple
-spontaneous
-mistaken as melanoma

Back 34

seborrheic keratoses

Front 35

-flesh-colored lesion
-dome shaped nodule
-central erosion
-occurs on facial skin or hands
-well-developed collarette

Back 35

Keratoacanthoma

Front 36

is a rapidly developing benign epidermal neoplasm that clinically and histologically may mimic well-differentiated squamous cell carcinoma

Back 36

keratoacanthoma

Front 37

how is a keratoacanthoma differientiated from squamous cell carcinoma?

Back 37

rapid growth
spontaneous remission

Front 38

may occur explosively in large numbers as a part of paraneoplastic syndrome: Leser-Trelat sign

Back 38

Seborrheic keratoses

Front 39

what is the 2nd most common type of skin cancer ?

Back 39

Squamous Cell Carcinoma

Front 40

what is the most common type of skin cancer?

Back 40

Basal Cell Carcinoma

Front 41

a malignant neoplasm of kertinocytes

Back 41

Squamous cell Carcinoma

Front 42

a malignant neoplasm of basal keratinocytes?

Back 42

Basal cell Carcinoma

Front 43

What are the demographics of Sqamous cell carcinoma?

Back 43

Males
>55

Front 44

What are the demographics of Basal Cell carcinoma?

Back 44

Males
>40

Front 45

Pearly papule or nodule containing prominent, dilated subepidermal blood vessels +/- ulceration

Back 45

Basal Cell Carcinoma

Front 46

what is the metastatic rate of squamous cell carcinoma?

Back 46

3-4%

Front 47

Which cell carcinoma may present due to HPV or chronic infection or industrial carcinogens?

Back 47

SCC

Front 48

urticaria
erythema multiforme
are examples of?

Back 48

acute inflammatory dermatoses

Front 49

psoriasis
seborrheic dermatitis
lichen planus
are examples of?

Back 49

chronic inflammatory dermatoses

Front 50

What is the length of acute inflammatory dermotoses flare ups?

Back 50

days ---> weeks

Front 51

What is the length of chronic inflammatory dermatoses flare ups?

Back 51

months ----> years

Front 52

Acute inflammatory dermatoses are characterized by?

Back 52

edema
+/- epidermal/vascular/subcutaneous injury

Front 53

-inlfammation
-altered epidermal growth (atrophy/hyperplasia)

Back 53

erythema multiforme

Front 54

what age group does urticaria most often affect?

Back 54

20-40yo

Front 55

What are the categories of urticaria causing agents?

Back 55

allergic: pollen, foods, drugs, insect venom

non-allergic: physical; pressure, hot/cold

Front 56

urticaria is a result of ________ process?

Back 56

IgE degranulation

Front 57

what is the age group erythema multiforme most commonly affects?

Back 57

NO age predilection

Front 58

is an uncommon, self-limited disorder that appears to be a hypersensitivity reaction to certain infections and drugs
-involving skin of hands and feet
-presents in a concentric ring form

Back 58

erythema multiforme

Front 59

sulfonamides, penicillin, barbiturates, salicylates, are examples of drugs that might instigate what sort of lesions?

Back 59

erythema multiforme

Front 60

These 4 main categories of culprits causing erthema multiforme?

Back 60

1) infections: herpes, mycoplasmal
2) drugs: penicillin, barbituates
3) malignant disease :carc-, lymphoma
4) Collagen vascular disease

Front 61

-a common
-chronic
-T-cell mediated inflammatory deramatosis
-2/3 w/ HLA Cw0602 allele

Back 61

psoriasis

Front 62

what is the demographics of psoriasis?

Back 62

- peak 22yo
- no gender predilection

Front 63

-salmon-colored plaque, w/ silver white scale
- nail changes present (30%)
- affects elbows, knees, scalp, penis

Back 63

psoriasis

Front 64

What chronic dermatoses is associated with :
-arthritis
-myopathy
-enteropathy
-spondylitic joint disease

Back 64

Psoriasis

Front 65

What are the 4P's regarding the presentations of Lichen Planus?

Back 65

pruritic
purple
polygonal
papules

Front 66

Oral lesions occur in ______% of Lichen Planus cases

Back 66

70

Front 67

What is the demography for Lichen Planus?

Back 67

Females
40-60 yo

Front 68

Wickham striae are white dots are lines associated with what lesions?

Back 68

Lichen Planus: chronic dermatoses

Front 69

Patients with Lichen Planus have an increase risk for developing what?

Back 69

SCC

Front 70

Lichen Planus =
lesions:Multiple/Single?
asymmetrical/symmetrical?
neck, trunk / extremities?

Back 70

multiple
symmetrical
extremities

Front 71

an inflammatory process that consists of tiny papules or macules
-erythematous
-greasy base
-scaly and crusty

Back 71

Seborrheic Dermatitis

Front 72

what is the seborrheic region that S. dermatitis will affect?

Back 72

scalp
forehead
eyebrows
folds (nasal/ paranasal)
retroauricular zone

Front 73

when is one likely to present with gradually with seborrheic dermatitis?

Back 73

fall and winter

Front 74

What are 2 examples of blistering disease?

Back 74

Bullous Pemphigoid
Pemphigus Vulgaris

Front 75

a distinct vesicobullous disease affecting elderly individuals characterized by formation of tense bullae

Back 75

Bullous Pemphigoid

Front 76

Pathogenesis:caused by antibodies directed against proteins at the dermal-epidermal junction (BP1 and BP2)
?

Back 76

Bullous Pemphigoid

Front 77

What % of Bullous Pemphigoid presents in the oral cavity?

Back 77

10-15%

Front 78

Immunofluorescence is a diagnostic tool for what 2 condtions?

Back 78

Bullous Pemphigoid
Pemphigous Vulgaris

Front 79

Which of the blistering diseases more commonly presents in the mouth?

Back 79

Pemphigous Vulgaris

Front 80

blistering disorder of adults (40-60 yo) characterized by superficial vesicles and bullae that are easily ruptured

Back 80

Pemphigous Vulgaris

Front 81

antibodies form against desmoglein-3

Back 81

Pemphigous Vulgaris

Front 82

What is the crucial therapy of Pemphigous Vulgaris preventing fatality?

Back 82

immunosuppresive therapy