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Definition of The Digestive Tract

Responsible for converting what we eat and drink into substances our bodies need to function

Food and Water Consumption

Substances our bodies need to Survive

Water, Proteins, Carbohydrates, Lipids, Amino Acids, Minerals, Vitamins

Ingestion

Food enters the GI tract through the oral cavity

Oral Cavity

Consists of the Mouth, Tongue, Teeth, Salivary Glands, Epiglottis, Pharynx, and Esophagus

Digestion

Food is passed from the oral cavity to the Stomach and Small Intestine, where it will then be broken down

Mechanical Digestion

A process where complex substances are broken down into smaller more absorbable pieces WITHOUT BEING CHEMICALLY CHANGED

Chemical Digestion

Complex Substances are CHEMICALLY BROKEN DOWN into smaller more absorbable pieces

Absorption

Material from the "Broken Down Food" can be used by the body is absorbed by the small and large intestines

Egestion

Indigestible material and waste must be removed by the body, so the materials are passed to the rectum and released through the anus

The Mouth

Consists of Cheek, Lips, Vestibule, Hard Palate, Soft Palate

Cheek

Supports the Oral Cavity and holds food

Lips

Keeps food in the mouth during chewing

Vestibule

Gap between lips and gum

Hard Palate

"Roof" of mouth supported by bone

Soft Palate

"Roof" of mouth supported by Skeletal Muscle

The Teeth

The primary Agent of Mechanical Digestion

How many sets of teeth do humans have?

Two:


20 Deciduous Teeth (Baby Teeth) which are replaced with 32 Permanent (Adult Teeth) 12 of which are molars

Regions of the Tooth

The crown ~> Top of The Tooth


The Neck ~> Central area that contains the gum and nerve endings


The Root ~> Area below the guns that contain blood on supporting structures

Enamel

Covers the Crown of the Tooth


Is the hardest substance in the Human Body

Nerves in the Tooth

Are found in the neck (register Sensation

Pulp Cavity

Hollow Tube that Runs through the middle of the tooth that contains blood vessels and nerve cells

Dentin

Hard Tissue that supports the enamel and DOES NOT CONTAIN NERVE ENDINGS

Periodontium

Holds the root of the tooth in the Jaw

Cementum

Bone with a high concentration of connective tissue

Gums

Tissue that surrounds and supports the teeth and associated tissues


AKA The Gingiva

Tinsils

Part of the Immune System


Act as a filter for foreign material in the mouth

Pharynx

Group of Muscles that Coordinate Swallowing


Controls the intersection between the Digestive And Respiratory System

Epiglttis

Found in the Pharynx


A flap of tissue that prevents food from entering the trachea

Eustachian Tube

Found in the Pharynx


Equalizes pressure between the Middle ear, throat, and nasal cavities

Salivary Glands

Produce saliva

Sublingual Glands

A set of Salivary Gland

Submandibular Glands

A set of Salivary Glands

Parotid Glands

A type of Salivary Gland

Saliva

Contains the enzyme Salivary Amylase


Contains various other enzymes that clean the surface of the mouth


Lubricates food

Salivary Amylase

Chemically breaks down STARCH into GLUCOSE (Hydrolosis)

Tongue

Primary Organ of the Oral Cavity


Contains 2 parts:


The root- Contains a series of muscles and nerve endings that link the tongue to the nervous system


The Body- involved in eating and drinking


Surface is covered in Papillae

Papillae

Taste Buds


Can only detect 4 tastes


"Salty, Sweet, Sour, and Bitter"



It is the proportions of these combined with our sense of smell that determines the "taste" of our food

The Esophagus

A long tube that connects the oral cavity to the stomach


Uses Peristalsis to move food down to the stomach

Swallowing => Stage 1

Food is Mechanically Digested by the Teeth


The Tongue mixes the mechanically digested mass with saliva from the salivary glands to form a Bolus

Swallowing => Stage 2

The tongue passes the bolus towards the pharynx


The pharynx forces the tongue to press against the hard and soft palate of the mouth

Swallowing => Stage 3

The Pharynx closes the Epiglottis which seals the Trachea so that food DOES NOT ENTER the respiratory system


The movement of the tongue triggers Peristalsis along the Pharynx and Esophagus that carries the bolus to the Stomach

The Stomach

Once the Bolus has been swallowed it moves down the esophagus into the stomach


A "J" shaped organ of the abdominal cavity where digestion occurs

Fundus

The first part of the Stomach closest to the Esophagus


Holds gases that are released during digestion

The Pylorus

The Third part of the Stomach


Closest To The Duodenum


The exit point of the stomach

How long does the Bolus spend in the stomach?

2-3 hours

Structure and Function of the Stomach

Entry into stomach is controlled by the Cardiac Sphincter

Cardiac Sphincter

A ring of muscle around the Pylorus


Makes sure food enters slowly


Prevents the backflow of food into the Esophagus

The Body of the Stomach

The stomach is lined with a mucous membrane called the Mucosa.


The biggest part of the stomach


Responsible for the formation of Chyme

Gastric Glands

What the Mucosa is composed of


Contains


Parietal Cells


Epithelial Cells


Chief Cells

Parietal Cells

Found in the Gastric Glands of the Mucosa


Produce Hydrochloric Acid (HCI) that is used to chemically break down proteins

Epithelial Cells

Produce Mucous that protects the stomach from the affects of Hydrochloric Acid (HCI)

Chief Cells

Produces the ENZYME Pepsinogen

Pepsinogen

Enzyme produced by Chief Cells


When Pepsinogen comes into contact with HCI it becomes active and is called Pepsin

Pepsin

Produced when Pepsinogen comes into contact with HCI


Speeds up process of Protein Digestion

Rennin

Secreted by the Mucosa


Slows the movement of milk and deprecated it into whey (will be digested where it is) and curds (carbohydrates) so that it can be digested and absorbed

Gastric Juices

The combination of Pepsin, Rennin, and Hydrochloric Acid in the Stomach

What Causes the stomach to contract?

The stomach is surrounded by a series of muscle layers that cause the stomach cavity to expand and contract

Rugae

Small ridges in the Mucosa

Formation of Chyme

As the stomach churns, food is mixed up and dragged across these ridges until it becomes liquid

The Duodenum

The first segment of the small Intestine and the second major site of digestion in the body


Chyme gets broken down further


90% of digestion occurs here with the help of accessory organs

Pyloric Spincter

A ring of muscle around the Pylorus


Controls the flow of Chyme from the stomach to the duodenum

What are the 3 "Juices" that are active in the Duodenum?

Pancreatic Juice


Bile


Intestinal Juice

Pancreatic Juice

Produced by the Pancreas


When the Acidic Chyme enters the Duodenum, the acid triggers the hormone prosecretin to activate into Secretin

What does Prosecretin activate into?

Secretin


When the acidic chyme enters the Duodenum the acid triggers the hormone to activate into Secretin

What does Secretin do?

Secretin triggers the Pancreas to start releasing Pancreatic Juice into the Duodenum through the Pancreatic Duct

What does Pancreatic Juice Contain?

Bicarbonate Ions


Trypsinogen


Pancreatic Amylase


Pancreatic Lipase

Bicarbonate Ions

Found in Pancreatic Juice


Act as a buffer and neutralize the acid in the chyme (raises pH from 2-6)

Trypsinogen

Activated into Trypsin in the Duodenum and breaks large polypeptides into diepetides

Pancreatic Amylase

Found in Pancreatic Juice


Breaks STARCH into GLUCOSE

Pancreatic Lipase

Breaks FAT molecules into FATTY ACIDS and GLYCEROL

Bile

Form of Mechanical Digestion


PRODUCED by the LIVER and STORED IN THE GALL BLADDER


NOT AN ENZYME


Emulsifies Fat MECHANICALLY

Cholecystokinin

A hormone that is released when fat reaches the Duodenum


Triggers the Gall Bladder to release bike into the duodenum through the Bile Ducts

What happens after Bile emulsified fat?

The smaller the fat molecules the easier it is for the enzymes to break them down CHEMICALLY into Glycerol and Fatty acids

Intestinal Juice

Produced in the duodenum by the KRYPTS OF LEIBERKUHN


Intestinal cells secrete fluid that contains the following Enzymes : Jntestinal Lipase


Erepsin


Disaccharases

Intestinal Lipase

Found in Intestinal Juice produced by the duodenum


Breaks fat globules into fatty acids and glycerol

Erepsin

Found in the Intestinal Juice Produced by the Duodenum


Breaks down proteins into Amino Acids

Disaccharases

Breaks Disaccharides into Monosaccharides

What is the major organ of digestion?

The small intestine

What does the Small Intestine do?

Major organ of Digestion and absorption

The Small Intestine

7m long


Attached to the abdominal wall by mesentary that contains blood supply

How many parts does the small intestine have?

3:


Duodenum


Jejunum


Ileum

Jejunum

Second part of the small intestine


LONGEST PART OF THE SMALL INTESTINE


Responsible for additional digestion and absorption

Ileum

FINAL SECTION IF THE SMALL INTESTINE


Absorbs remaining nutrients from the chyme

The Mucosa

Inner lining of the stomach


Arranged in ridges call villi

What is the difference between Rugae and Villi?

The Rugae are found in the stomach whereas the Villi are found in the small imtestine

Villi

Ridges in the Mucosa


Increase surface area of the small intestine in order to allow for more efficient absorption of nutrients


Each Villus contains many structures :


Epithelial Cells


Krypts of Leiberkuhn


Lacteal


Capillaries

Krypts of Leiberkuhn

Digestive glands found at the base of the villi (that are in the DUODENUM and JEJUNUM)


Release intestinal Juice

The Lacteal

A lymph vessel that absorbs the fatty acids and glycerol

Cuboidal Cells

Lining of the villi that contain MICROVILLI to increase surface area

Capillaries

Nutrients move through the Cuboidal cells into the Capillaries.


Absorb:


Monosaccharides, amino acids, vitamins, minerals INTO THE BLOOD

Purpose of The Small Intestine

In the presence of food it is ALWAYS MOVING

4 Main Function of the Small Intestine

Squeeze Chyme through the Intestine


Mix Chyme with the Digestive Enzymes


Break Down food particles MECHANICALLY


Speed up absorption by bringing the Chyme into Contact with Mucosa

Enzymes

A biological Catalyst that SPEEDS UP CHEMICAL REACTIONS WITHOUT BEING CONSUMED OR ALTERED


Will lower the activation energy, thus making it easier for a CHEMICAL REACTION TO TAKE PLACE


Protein Molecules

The Active site of an Enzyme

A region where the REACTANTS binds and where the chemical reaction TAKES PLACE


When the reaction has taken place the substrate is released from the active site and the ENZYME REMAINS UNCHANGED

Substrate

A Reactant that binds to the active site of an enzyme

What is a Reactant?

A substance that is going to react

How many substrates can bind to the active site of an enzyme?

More than one substrate can bind to the active site of an enzyme depending on the type of reaction that will take place

What is the Enzyme-Substrate complex?

The binding of the Substrate to the active site of an Enzyme

Inhibitors

When an Enzyme is not needed an Inhibitor will bind to the enzymes active site


This BLOCKS THE SUBSTRATE THUS PREVENTING A CHEMICAL REACTION FROM OCCURING

The Large Intestine

Undigested and Unabsorbed material pass from the small intestine to the large intestine


~1.5m long


NO DIGESTION OCCURS IN THE LARGE INTESTINE


Contains 5 Parts:


Cecum


The Appendix


The Colon


The Rectum


The Anus

What percentage of digestion occurs in the large attention?

NO DIGESTION OCCURS IN THE LARGE INTESTINE

Cecum

First part of the Large Intestine


Chyme enters through the illocecal valve


Contains intestinal Bacteria that breaks down cellulose that is still present in the Chyme

Illocecal Valve

The entry point of the Cecum from the Small Intestine


Chyme first enters the Large Intestine through here

Why is Cellulose important for digestion?

Cellulose of "Bulk-Fibre" that is used to trigger bowel movements

The Appendix

Second "Part" of the Large intestine


Stores the small amount of Cellulose that is broken down by intestinal bacteria


A vestigial organ (no function)


If inflamed it can rupture

Intestinal Bacteria

Found in the Cecum


Breaks down Cellulose that is still present in the chyme

The Colon

Third "Part" of the Large Intestine


Divided into the Ascending, Transverse, Descending, and Sigmoid regions


Absorbs Vitamins B and K

Where is Water reabsorbed in the body?

In the Colon (Large intestine)


As chyme passes through the regions of the colon, water is reabsorbed

How much of the digestive fluid is used by the body each day?

7L of the body's digestive fluid is used everyday

The Rectum and The Anus

The edge of the Large intestines


Feces is passed to the holding area (Rectum) until a bowel movement occurs


The regular the bowel movements are, the less time the toxins can stay in the body

What is the Anal Sphincter?

The ring of muscle that controls the exit of the GI Tract

Feces

Undigestible remains of the CHYME


~ 60% solid, 40% liquid


Contains Bile, Cellulose, Bacteria, Water, and other materials the body can't use

Diarrhea

When too little of the water drank is absorbed by the intestine

Constipation

Too much water is reabsorbed by the body

The Liver

A two lobed organ associated with DIGESTION and FILTRATION and STORAGE

Where does the liver receive its blood supply?

Hepatic Artery

Where does the liver receive the blood it is to filter?

The HEPATIC PORTAL VEIN from the INTESTINES

Where does the filtered blood exit the liver to return to the heart?

Hepatic Vein

Liver Filtration

After nutrients are reabsorbed by the VILLI, the blood is carried to the Liver via the HEPATIC PORTAL VEIN

What does the Liver remove from the blood?

Any toxins that may be present in the blood.

Blood Sugar Maintenance

The LIVER ACTIVELY REMOVES GLUCOSE FROM THE BLOOD


Excess Glucose is converted into Glycogen and stored in the LIVER

What Happens when there is a drop of glucose levels in the blood?

Is there is a drop of glucose levels, the liver will convert the Glycogen into Glucose

Liver Waste Management

The LIVER converts AMINO ACIDS and AMMONIA into UREA which is then removed from the body

What does the Liver store and produce?

The liver stores VITAMINS A, D, B12 and IRON


The Liver produces Vitamin A, and CHOLESTEROL used in the formation of the cell membrane


The Liver also produces proteins for blood clotting and globulins to fight infections

What is Stored in the liver?

Vitamins A, D, B12 and Iron

What is produced by the Liver?

Vitamin A, Cholesterol, and Proteins used for blood clotting and Globuling to fight infections