Dermpath Neoplasms - Really Rough Draft Of Cards

Front 1

em of melanosome

Back 1

melanosome 4 stages- stage 2 - can tell it's a melanosome, stage 3 with pigmentation
elongated football shaped structure with lines in cytoplasm

Front 2

blue nevus

Back 2

pigmented lesion spares epidermis, involves superficial dermis, heavily pigmented dendritic melanocytes (long, wavy)
increased fibroblasts and thicker collagen - NO EPIDERMAL INVOLVEMENT
hmb45 is positive

Front 3

cellular blue nevus

Back 3

children, lumbosacrum, dumbbell shaped, bullous base
cells that pigmented wavy dendritic melanocytes
islands of spindled/epithelioid (pale abundant cyto, little to no pigment)
macrophages in background
NO EPIDERMAL INVOLVEMENT

Front 4

deep penetrating nevus, plexiform spindle cell nevus

Back 4

bulky melanocytic lesion; occurs in upper back, shoulder
wedge-shaped
fascicles/plexiform of spindle-epitheloid abundant, finely pigmented cytoplasm
macrophages
no or few mits

Front 5

abc cells of nevus

Back 5

A - epitheloid (most superficial)
B - lymphocyte
C - neural cells

Front 6

Spitz nevus (spindle and epitheloid cell nevus)

Back 6

children most commonly
low mag - symmetric
epidermal hyperplasia
nests in junction (vertical orientation, bunch of bananas)
cells disperse as single cells at base
High mag up near junction - kimono bodies (eosinophilic lobules of BM material - right beneath epidermis), large nuclei, prominent nucleoli (smooth contours, fine chromatin), cytoplasm - amphophilic, delicate
can have pagetoid spread, focally, groups, in center

Front 7

what benign pigmented lesions can have pagetoid spread

Back 7

spitz nevus
acral nevus
recurrent nevus
congenital nevus

Front 8

melanoma SS types limited set of fx

Back 8

pagetoid spread (even into corneum), diffuse
no maturation

Front 9

four types of melanomas

Back 9

lentigo maligna - face, elderly, sun-damaged skin; if invasive spindled or desmoplastic, can run down hair follicle
SS - 70%, nests and single
acral/mucosal/lentingous type - pigmented lesion with increase of continguous DE junction
nodular melanoma - no epidermal component

Front 10

radial growth phase

Back 10

in situ vs non tumorogenic

Front 11

vertical growth phase

Back 11

large in dermis is larger than any nest in epidermal or any dermal mits

Front 12

how know on face

Back 12

increased sebacous elements

Front 13

b cell lymphoma how to distinguish between melanoma and lymphoma

Back 13

b cell lymphoma - bottom heavy, bulky, spares epidermis, diffuse blue, no follicle formation
primary and secondary forms
nodular melanoma vs. lymphoma - high mag and look for pigment, look more superficially for that pigment
look for DE junction component

Front 14

what

Back 14

steatocystoma (multiplex)
epithelial lined cyst with no granular layer, corregated eosinophilic lining

Front 15

what

Back 15

warty dyskeratoma (like darier's but isolated and centered on H&N, genital)
solitary lesion, face, cup-shaped invagination, filled with keratin, corrons, corgrains

Front 16

large cells with ample cytoplasm, prominent nucleoli, large nuclei, all layers, compress adjacent keratinocytes

Back 16

paget's - do ihc

Front 17

extramammary pagets

Back 17

primary, originates from apocrine glands at those sites, vulva, anogenital (less associated with underlying neoplasm)

Front 18

what

Back 18

circumscribed, dermis, two cell types, basophilic (matrical), ghosts cells (shadow cells), FBGCrxn, calcium
pilomatricoma

Front 19

sebaceous adenoma

Back 19

well-circumscribed, lobular, uniform sebaceous cells, nucleus can be scalloped, not assoc with follicle
two cells: peripheral basaloid cells, mature sebaceous cells (if adenoma 50% sebacous; if sebaceous epithelioma more of the peripheral cells; if carcinoma, on eyelid, aggressive)

Front 20

what is assoc with muir torre syndrome

Back 20

sebaecous carcinoma, while carcinoma less aggressive than sporadic

Front 21

nevus sebaceous

Back 21

abortive hair follicles, epidermal hyperplasia, sebaceous hyperplasia, ectopic apocrine gland formaiton

Front 22

most common b9 and malign neoplasms to develop within nevus sebaceous

Back 22

syringocytoadenoma papillerfum
bcc

Front 23

hidradenoma papilleferum

Back 23

females, genital/vulvar
circumscribed, papillary, one-two cell layers, no connection to overlying epidermis, apocrine decapitation secretion

Front 24

what

Back 24

papillary, connects to epidermis, packed with plasma cells, apocrine decap secretion
scalp, face
syringocystadenoma papillerfum

Front 25

what

Back 25

pieces of jigsaw puzzle, two cell types, darker peripheral cells, central pink cells, basement lamina-material
tubular lumina (eccrine origin)
cylindroma

Front 26

??

Back 26

like cylindroma: two cell types, darker peripheral cells, central pink cells, basement lamina-material
tubular lumina (eccrine origin)
but anatomosing cords

Front 27

syringoma

Back 27

tadpole lesions, epithelial cells with tails
dense collagen background
protein debris (sweat jello)

Front 28

mac

Back 28

follicular/eccrine differentiation (latter at base)
deep infiltrative

Front 29

what

Back 29

epidermal hyperplasia, elongation of rete ridges and basal hyperpigmentation (dirty fingers), grenz zone, spindle cell proliferation, entrapment of keloidal fibers
dermatofibroma

Front 30

ihc for dermatofibroma

Back 30

13a + cd34-

Front 31

dfsp

Back 31

infiltrative, spindle cells, honeycomb of fat, storiform

Front 32

ihc of dfsp

Back 32

13a-, cd34+

Front 33

what

Back 33

similar ihc to dfsp, in kids, vascular like spaces, multilobated cells
giant cell fibroblastoma (juvenile counterpart to dfsp)

Front 34

what

Back 34

elderly, exophytic, ulcerated, atypical pleomorphic cells, high mits
AFX

Front 35

"mfh is a deeper form of"

Back 35

AFX

Front 36

what

Back 36

epidermal hyperplasia, dilated spaces right up to epidermis, protein debris (lymph fluid)
lymphangioma circumscriptum

Front 37

what, ass/w

Back 37

dilated spaces with blood abut epidermis
angiokeratoma
fabry's

Front 38

what, a/w

Back 38

associated with Castlemans
glomeruloid hemangioma

Front 39

kaposi's sarcoma - evolution

Back 39

increased in slit-like vascular spaces, increased dermal spindle cells, promitory sign
spindle cells proliferative, hyaline globules
nodular formation with loss of vascular proliferation

Front 40

four flavors of kaposi's

Back 40

-all HHV8 associated
- aids associated one, visceral more common

Front 41

angiosarcoma

Back 41

vascular spaces, atypical cells

Front 42

three clinical settings for angiosarcoma

Back 42

1. elderly, white
2. chronic lymphadema (stuart-treves)
3. irradiated sites

Front 43

glomus tumor

Back 43

uniform round cells
HAND glomus body is a modified smooth muscle cell
solid form
if thin walled vessels (glomangioma)
if smooth muscle glomangiomyoma

Front 44

ihc for spindle cell lipoma

Back 44

cd34 +

Front 45

sites of granular cell tumor

Back 45

tongue, skin

Front 46

merkel cell

Back 46

skin, elderly, extremities
neuroendocrine chromatin pattern with little cytoplasm, molding
dot perinuclear staining of CK20

Front 47

gorlin's syndrome

Back 47

basal cell syndrome
AD
patched, czome 9
numerous basal cell carcinomas
associations: OKCs, palmar pits, rib abnormalities, medulloblastomas, calcificaiton of falx

Front 48

muir torre syndrome

Back 48

AD
HNPCC MSI mlh1 msh2
sebaceous tumors, colon, gu, endometrial tumor

Front 49

burk hogg dube

Back 49

AD
renal tumor/oncocytic, pulmonary cysts

Front 50

cowden

Back 50

AD
czome 10
trichellommas, breast and thyroid

Front 51

gardners

Back 51

AD
czome 5 apc
EICs, osteomas, polyps, desmoid tumors

Front 52

Peutz jeghers

Back 52

pigmented macules lips
hamartomatous polyps, colon carcinoma

Front 53

TS

Back 53

AD
two proteins:
angiofibromas (adenoma sebaceum),
cns hamartomas, subependymal
angiomyolipoma, etc

Front 54

NF1

Back 54

pheo

Front 55

cerebral, a/w

Back 55

pheo
cerebral hemangioblastomas
skin: angiomatosis
vhl

Front 56

men 2b

Back 56

ret gene, pheochromocytoma