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41 Cards in this Set
- Front
- Back
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what goes wrong in basal cell nevus syndrome
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inactivation of tumor suppressor genes
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nevi originate from _____ that migrate from the neural crest to the epidermis
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melanoblasts
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what are three types of nevi
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junctional
compound dermal |
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giant congenital nevi are at risk of ____
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melanoma
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______ nevi are usually not evident until puberty and continue todevelop over a lifetime
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dysplastic
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what is a common site of dysplastic nevi
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trunk
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melanoma accounts for ___% of all skin cancer deaths
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75
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malignant melanomas evolve from melanocytes at the _____ junction
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dermoepidermal
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what other cancer is associated with familial melanoma
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pancreatic
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what are four melanoma subtypes
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superficial spreading
nodular lentigo maligna acral lentiginous |
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melanoma with long radial growth phase followed by rapid vertical growth phase. 60-70% of all melanomas
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superficial
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what is the fastest growing melanoma
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nodular
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is nodular melanoma 15-30% a short or long radial growth phase?
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short
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which melanoma has highest risk of metastasis
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nodular
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which melanoma is typically onset after age 70
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lentigo maligna
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what melanoma is most common in darker skin types
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acral lentiginous melanoma
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what melanoma looks like seborrheic kearotis
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lentigo maligna
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which melanoma has longest radial growth phase
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letnigo
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which melanoma is hutchinson sign for
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acral lentiginous
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which organs are likely metastasis for melanoma
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skin lung and liver
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are epidermoid cysts compressible?
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yes
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when are seborrheic keratoses onset
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fourth or fifth decade
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which disease looks like barnicle
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seborrheic keratoses
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what are pseudohorn cysts associated with
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seborrheic keratoses
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how do you treat seborrheic keratoses
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curette
cryo |
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what are the risk factors of AK
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fair skin
males increasing age intense sun |
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which CC is more common in immunocompromised patients
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SCC
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what is bowen's
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SCC in situ
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where else should you look for SCC
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lips ears perianal genials and hands
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what might cause SCC
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UV damage
HPV chronic inflammation |
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what are the clinical features of SCC
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erythematous indurated base
thick overlying scale nodular and or ulcerated |
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what might look like SCC
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superficial BCC
AK eczema psoriasis |
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what are high risk areas for BCC
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central face
postauricular pinna ear canal forehead scalp what |
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what are three types of BCC
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nodular
superficial morpheaform |
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what is the most common subtype of BCC
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nodular
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describe nodular BCC
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pearly
telangiectasias rolled border friable |
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describe superficial BCC
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trunk and extremities
erythematous thin plaque with overlying scale |
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what is the most aggressive type of BCC?
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morpheaform
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why should you always do mohs with morpheaform BCC
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because ti's most aggressive subtype
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what does morpheaform BCC look like?
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scar like hypopigmented papules with indistinct margins
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what do you use mohs for
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recurrent BCC and SCC
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