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45 Cards in this Set
- Front
- Back
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what are the two layers of the dermis?
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papillary and reticular
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what is the primary type of collagen of the dermis
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Type I
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collagen within the ______ dermis is coarser and houses larger blood vessels and nerves
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reticular (deeper)
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______ are organized networks of collagen, elastin, glycproteins, and proteoglycans
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ECM
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collagen forms a braided fibril comproised of three
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alpha chains
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what is ehler danlos a disorder of
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genetic disorder of collagen synthesis
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describe EDS type !
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hypermobility of joints
excessive stretching of skin with maintenance of elastic recoil fragile skin atrophic fish mouth scars |
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pt presents with brusing and GI and arterial rupture. You counsel them to avoid contact sports. What could it be?
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type IV ehlers danlos
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elastic fibers are primarily composed of ____ and _____
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elastin and fibrillin
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an autosomal dominant disease resulting from clumping of elastic fibers
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PXE
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what else do you need to worry about with PXE
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skin
eyes CV |
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finding is yellow papules of the lateral neck and axillae. Onset first or second decade of life but not clinically apparent till third..
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PXE
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T or F. PXE involves eyes 100% of the time
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TRUE-- acuity and rarely blindness
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what three docs should manage PXE
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cardiologists
dermatologist opthamologists |
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why are scars less elastic than normal skin
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because elastic fibers are only synthesized during growth and deelopment. Only collagen is replaced throughout life.
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what two neurovascular plexuses are in the dermis
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superficial plexus
deeper horizontal plexus |
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T or F. the epidermis is vascular
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FALSE avascular
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clinical appearance is reticulated macular erythema.
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livedo reticularis-- a disorder of cutaneous vasculature
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appearance is palpable purpura in legs and ankels as a reaction to a medication
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leukocytoclastic vasculitis LCV
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what is the complication of LCV you need to watch out for
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renal insufficiency due to inflammation of vasculature of the kidney
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what causes LCV
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reaction to medications, infection, or autoimmune
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what is the difference between partial and full thickness wounds
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epidermis + superficial dermis
dermis |
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what are the three wound healing phases
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hemostasis
proliferative maturation |
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what are the three parts of the inflammatory phase of wound healing
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hemostasis
vascular response immune response |
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what are the three parts of the proliferative phase of wound healing
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cellular response
vacular response epithelialization |
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what is the final wound strength in %
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70 to 80%
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how long after a wound do you reach 20% of final strength
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3 weeks
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_____ stimulate platelets to undergo activation, adhesion, and aggregation
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collagen
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excess collagen deposition
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keloid
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who is at highest risk for keloids
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blacks and mediterannean
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what is a pyogenic granuloma
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rapidly growing, friable vascular lesion that bleeds easily and arises at sites of trauma. proliferating vascular tisuse fails to reepithelialize unless the lesion is cauterized or surgically removed
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hypocellular thickening of collagen
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sclerosis
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what are two types of scleroderma
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morphea
systemic |
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describe morphea
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scleroderma (hypocellular thickening of collagen)
erythematous plaque that is indurated. central portion is hypopigmented with lilac ring. associated raynaud's |
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where is morphea most commonly found
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trunk
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T or F. biopsy can help distinguish morphea from systemic sclerosis
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false
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what is CREST syndrome
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systemic sclerosis
Calcinosis cutis raynaud's esophageal dysmotility scelerodactyly telangiectasias |
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what other organs shoudl you worry about with CREST
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pulmonary fibrosis renal insufficiency, cardiac
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what disorder of subq do you know
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panniculitis
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what is panniculitis
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inflammatory disorder of the subq fat. presents as tender, erythematous, non ulcerated nodules with ill defined borders.
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where is the most common place of panniculitis
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lower extremities
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what is the most common type of panniculitis
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erythema nodosum EN
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what is EN
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hypersensitivity reaction to variety of antigenic stimuli. inflammation of the fibrous septae that separate the fat lobules
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what causes panniculitis
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medications (contraceptives!!)
infections sarcoidosis IBD |
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how do you treat panniculitis
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remove offending meds. rest, elevation, compression, NSAIDs
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