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11 Cards in this Set
- Front
- Back
- 3rd side (hint)
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IL-1 |
Secreted by macrophages. Endogenous pyrogen. Causes fever, acute inflammation, activated endothelium adhesion molecules, induces chemokine secretion |
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IL-6 |
Secreted by macrophages and Th2 cells. Endogenous pyrogen. Causes fever |
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IL-8 |
Secreted by macrophages. Major chemotactant for neutrophils |
Clean up on aisle 8 |
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IL-12 |
Secreted by macrophages and B cells. Induces differentiation of T cells into Th1 cells and activates NK cells |
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TNF-alpha |
Secreted by macrophages. Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak |
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IL-2 |
Secreted by all T cells. Stimulates growth of helper, cytotoxic, and regulatory T cells |
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IL-3 |
Secreted by all T cells. Supports growth and differentiation of bone marrow stem cells. Functions like GM-CSF |
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Interferon-gamma |
Secreted by Th1 cells. Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and intitumor properties |
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IL-4 |
Secreted by Th2 cells. Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG |
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IL-5 |
Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates the growth and differentiation of eosinophils |
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IL-10 |
Secreted by Th2 cells and regulatory T cells. Modulates inflammatory response. Inhibits actions of activated T cells and Th1 cells |
TGF-beta has similar actions to IL-10 because it is involved in inhibiting inflammation |
