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17 Cards in this Set
- Front
- Back
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Il-1
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S: Monocytes macrophages
Most potent Pyrogen, Induces Il-2R expression and IL-2 synthesis in T cells; Enhances adhesion molecule expression |
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IL-2
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S: TH0, TH1 cells
T-Cell growth factor, Target of many immuno-suppresants |
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IL-3
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TH Cells
Stimulates hematopoiesis |
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IL-4
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S: TH2 cells, mast cells, basophils
Promotes Th2 development, inhibits TH1 development; promotes IgE and IgG4 synthesis in b cells |
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IL-5
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S: TH2 cells
Eosinophil development; class switching to IgA in B cells |
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IL-6
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T cells, B cells, macrophages and others
Stimulates APP and antibody synthesis; wussy pyrogen |
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IL-7
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S: Bone marow and thymic stromal cells, some T-cells
Growth factor for pre-t and pre-b cells |
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IL-8
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S: Macrophages, others
Chemotactic for neutrophils and naive T cells |
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IL-10
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S: Treg
Inhibits Th1 and macrophages, autoimmunity |
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IL-12
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S: Activated macrophages, dendritic cells, B Cells
Activates TH1, NK, and Tc cells |
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IL-13
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S: TH2 cells
B cell growth factor; class switch to IgE |
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IL-17 family
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S: Th17 cells
Pro-inflammatory, chemotactic for neutrophils, autoimmunity and hypersensitivity reactions |
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IFN-Alpha and IFN Beta
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S: Many cell types
Induced by viral infection and ds RNA; anti-viral; induces class 1 MHC expression |
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IFN Gamma
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S:TH1 cells
Selects TH1, Inhibits Th2, activates macrophages, NK and Tc cells; promotes MHC 1 and 2 |
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TNF-Alpha
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S: Macrophages
Inflammation, Vasc. Extravasation; enhances phagocytosis and respiratory burst in macrophages; induces fever, APP release, septic shock, cachexia (weight loss) |
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TGF Beta
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S: Treg cells
Stimulates IgA production, inhibits cell-mediated immunity; anti-inflammatory; promotes fibroblast growth and wound healing |
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Gm-CSF
M-CSF G-CSF |
S: T cells, monocytes
Promotes growth of granulocytes and monocytes according to name |
