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11 Cards in this Set
- Front
- Back
- 3rd side (hint)
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IL-1
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endogenous pyrogen, causes fever and acute inflammation.
activates endothelium to express adhesion molecules. induces chemokine secretion to recruit leukocytes |
secreted by: macrophages
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IL-6
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endogenous pyrogen, fever.
stimulates production of acute-phase proteins |
secreted by: macrophages, also Th2
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IL-8
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major chemotactic factor for neutrophils (pus)
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secreted by: macrophages
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IL-12
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induces differentiation of T cells into Th1.
activates NK cells |
secreted by: macrophages, also B cells
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TNF-a
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mediates septic shock.
activates endothelium, leukocyte recruitment, vascular leak |
secreted by: macrophages
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IL-3
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supports growth and diff'n of bone marrow stem cells (fxns like GM-CSF)
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secreted by: all T cells
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IL-2
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stimulates growth of helper and cytotoxic T cells
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secreted by: Th1
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interferon-gamma
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activates macrophages and Th1 cells.
suppresses Th2 cells. (antiviral and antitumor) |
secreted by: Th1
induce production of ribonuclease that inhibits viral protein synthesis by degrading viral mRNA (but not host mRNA); increase MHC I and II expression and antigen presentation |
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IL-4
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growth of B cells, class switching to IgE and IgG.
differentiation into Th2 cells. |
secreted by: Th2
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IL-5
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differentiation of B cells, class switching to IgA.
differentiation of eosinophils. |
secreted by: Th2
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IL-10
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modulates inflam response. inhibits T and Th1, activates Th2
(similar actions by TGF-beta) |
secreted by: Th2, also regulatory T cells
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