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24 Cards in this Set
- Front
- Back
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IL-1
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Macs, endothelial
proinflammatory, actives endothelium, induces cytokines; fever |
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IL-2 (T-cell growth factor)
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T cells, thymocytes, NK
T,B,NK act/prolif |
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IL-3 (Multi-CSF)
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T cells
development of hematopoetic |
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IL-4 (TH2, Mast cells)
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Isotype swithc to IgE
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IL-6
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Macs, T cells
induces actue phase proteins from liver, plasma cell prolif |
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Il-5
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TH2
Eosinophil recruitment and activation, isotype switch to IgA |
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IL-7
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BM stromal cells
survival and expansion of lymphoid progenitors, survival or naive memory T cells |
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IL-8 (CXCL8)
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Leukocytes, endothelia, fibroblasts
Chemokine for neutrophil recruitment |
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IL-10
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TH2, Treg, Macs
Inhibits Macs and Dendritic cells |
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IL-12
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dendritic cells, macrophages
stimulates IFN gamma; production of TH1 cells |
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IL-13
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Th2, basophils
anti-parasite; isotype switch to IgE |
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IL-15
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macs
NK and CD8+ T cell proliferation |
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IL-17
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Th17 cells
proinflammatory; recruits neutrophils |
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IL-18
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DC, Macs
Pro-inflammatory; enhances T and NK cell maturation, cytokine production and cytotoxicity |
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IL-22
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Th17 and act. NK
Acts with IL-17 to induce anti-microbial peptides (e.g. defensins) from keratinocytes |
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IL-23
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DC, Macs
Expands and maintains TH17 cells |
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IL-35
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DC, Macs
Expands CD4+CD25+Tregs, suppresses CD4+CD25-effectors, inhibits Th17 cell polarization |
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Type I Interferon (interferon- alpha/beta
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Many cell types
Anti-viral effects |
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Type II Interferon ( interferon gamma)
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Macrophage activation, production of TH1; increased MHC expression
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TNF alpha
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Macs, T cells
Pro-inflammatory; activates endothelium, induces cytokines |
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TGF-beta
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Treg, Macs
Inhibits proliferation and activation of lymphocytes; inhibits Mac activation, promotes isotype switch to IgA |
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G-CSF
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Macs, BM stromal cells, endothelial
Differention and growth of granulocytes |
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GM-CSF
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Macs, Endothelial, T cells
Differentiation and growth of granulocyte and monocyte progenitors; activation of Macs, development of osteoclasts |
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TSLP
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gut epithelial and mesenchymal cells, thymic epithelial
influences Th2 response; acts with TGF beta and PGE2 to maintain Dendiritcs in quiescent state |
