Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
IL-1 |
Made by large range of cell types, but most importantly macrophages and dendritic cells. Activates many cells including T and B cells. Along with IL-6 stimulates fever (endogenous pyrogen) |
|
|
IL-2 |
T cell growth factor Essential for both helper and cytotoxic T cell activation, proliferation Produced by activated CD4+ helper T cells |
|
|
IL-4, IL-5 |
B cell growth factors Produced by activated CD4+ helper T cells mostly. Can by produced by mast cells and NK cells. Fundamental component of T cell "help" for B cells. Required for isotype switching. |
|
|
IL-6 |
Made by macrophages (and other cells) in response to a number of different classes of microbial antigens. Stimulates resting (not already activated) T cells, and other cell types. Also supports growth of B cells and differentiation into plasma cells. |
|
|
IL-10 |
Causes suppression of production of other cytokines. Decreases expression of MHC class II molecules. General immune suppressive effects. Produced by CD4+ helper T cells. Also produced by UV treated epidermal cells. |
|
|
IL-12 |
Also called T cell-stimulating factor. Produced by macrophages and dendritic cells. Influences a bias in CD4+ T cells. Increases gamma interferon production. Can make autoimmune disease worse. May inhibit allergic responses. (it may inhibit allergic responses) |
|
|
IFN alpha, beta |
Type I. Produced by most cell types. Binds to IFN-AR (alpha receptor) Makes surrounding cells more resistant to the virus.--probably through inhibition of protein synthesis. Also initial defense during viral infection. |
|
|
IFN gamma |
Type II. Produced by activated NK and T cells. Specifically CD4+ helper and CD8+ cytotoxic T cells. Binds to the IFN-GR(gamma receptor). Activates macrophages=increased phagocytosis, respiratory activity, killing of bacteria, and MHC II expression |
|
|
IFN lambda |
Type III. Also called IL-28 IL-29. Recently discovered (2002). Binds to the IL10R2 and IFNLR1 complex. Trigger Type I like IFN response on a restricted subset of cells. |
|
|
IL-17 |
Made by Th17. Pro inflammatory, and immune response. Over activity linked to autoimmune disease. Stimulates other cytokines (IL-6) chemokines. |
