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8 Cards in this Set
- Front
- Back
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define Arteriosclerosis
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The generic term for thickening, hardening & loss of elasticity of the arterial wall
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what are the 3 types of ateriosclerosis? tell a bit about them
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Atherosclerosis: involvement of large/medium size vessels
Mönckeberg arteriosclerosis (medial calcific): not important dont worry Arteriolosclerosis: small vessel disease |
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what is the number one organ effected by arteriolosclerosis?
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Kidney
(small vessel disease) |
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What is the pathogenesis of atherosclerosis?
***TEST |
The response to injury hypothesis
chronic endothelial injury accumulation of lipoproteins (LDL mainly) oxidation of lipoproteins adhesion of monocytes & other leukocytes release of platelet factors → migration of smooth muscle cell into intima proliferation of SMC’s ↑ accumulation of lipids |
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what are fatty streaks? what are they seen in?
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lipid laden macrophages & SMC’s
complicated plaques – calcified, fissured, ulcerated seen near major vessel bifurcations (aorta, etc) this is seen in gross morphology of atherosclerosis |
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if a person has an aneurysm, how big does it have to be when you just say...sorry can't do anything about it
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greater than 5 cm
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what is arteriolosclerosis secondary to?
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hypertension and/or diabetes
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what are the 2 types of arteriolosclerosis ?
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hyaline – diffuse thickening of arteriolar walls (benign nephrosclerosis)
hyperplastic – malignant hypertension (systolic >200, diastolic > 120) ± 5% of hypertensive patients |
