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15 Cards in this Set
- Front
- Back
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What types of rash orginate in the epidermis? |
Eczematous Psoriasiform Lichenoid |
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What skin condition result when blood vessels in the dermis become leaky? |
Uticaria |
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What are some cutaneous manifestations of Cushing's syndrome? |
Skin thinning Easy brusing Striae Athrophy Acne |
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Why do people with primary adrenal failure get pigmentation? |
ACTH is produced as part of a long peptide also containing POMC therefore as more ACTH is made more POMC is made. POMC stimulates melanocytes resulting in increased pigmentation. |
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What diagnosis should be considered in someone with periorbial oedema? |
Hypothryoid |
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What cutaneous signs are present with hyperthyroidism? |
Mucin deposits give rise to exothalmos, thyroid acropathy (psudoclubbing) and pre-tibial myxodema |
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Decribe the pathogenesis of porphyrias |
There are eight different types and each is due to the parital deficiency of one of the enzymes involved in haem synthesis. The enzyme deficiency results in the overproduction and increased excretion of toxic haem precursors (porphrins and/or their precursors) |
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Which of the porphyrias does not have cutaneuous manifestations? |
Acute imtermittent porphyria |
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What is the prevalence of porphyria cutanea tarda? |
1 in 25000 |
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Which areas of skin are likely to develop porphyria related lesions? |
Sun exposed |
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What skin lesions are present in PCT? |
Erthema and bullae that occur on exposure to sunlight Fragile skin healing with puritis Hyperpigmentation Hypertrichosis |
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What diseases is PCT associated with? |
HIV Haemochromatosis SLE Alcoholic liver disease Chronic active hepatitis |
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What kind of rash would be associated in someone with type 1 diabetes? |
necrobiosis lipoidica |
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What skin lesion is associated with UC and Crohn's disease? |
Pyoderma gangrenosom |
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What condition is Pyoderma gangrenosom commonly mistaken for? |
Necrotising fasciitis |
