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33 Cards in this Set
- Front
- Back
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lysozyme
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bacterial fighting protein
alters the permeability of bacterial cells by interfering w/ their cell walls |
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lactoferrin
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chelates iron molecules that is necessary for bacteria to survive
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lactoperoxidase
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blocks bacterial enzymes so that they can’t proliferate
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immunoglobulins
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cause the bacteria to clump together (like mucin does)
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Saliva components
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99% water
electrolytes = Na+, K+, Ca++ bicarbonate & phosphate buffers = to maintain pH 6.7 – 7.4 desquamated EP cells salivary corpuscles = degenerating WBC’s from the tonsils enzymes Mucin & Epidermal Growth Factor = for wound healing & repair |
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Minor Salivary Gland
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don’t require stimulation
they are constantly secreting |
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Major Salivary Glands
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secrete under specific stimuli
bilaterally paired, lobed, lobulated, acinated |
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Which salivary gland is the last to form?
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Sublingual
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Parotid Gland
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largest major salivary gland
secretion is purely serous secretes the most amount of saliva when stimulated has a lot of adipose tissue Stenson’s Duct = opens opposite the Mx 2 nd molar |
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Submandibular Gland
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secretion is mixed, but mostly serous
secretes the most amount of saliva in resting conditions has serous alveoli, mucous alveoli, mucous alveoli + serous demilune Wharton’s Duct = opens up on each side of the lingual frenulum |
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Which gland secretes the most amount of saliva in resting conditions?
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Submandibular
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Which gland secretes the most amount of saliva when stimulated
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Parotid gland
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Sublingual gland
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smallest major salivary gland
secretion is mixed, but mostly mucous NO well-defined CT capsule because oral cavity floor CT is sufficient to protect it NO serous alveoli! - only mucous alveoli, and serous demilunes intercalacted and secretory ducts are absent / reduced |
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What gland has excretory ducts that make up the main duct system?
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Sublingual
There are no intercalated and secretory ducts |
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Basket cells / Myoepithelial cells
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present in all major salivary glands
sits on top of the BM squeezes the cell & intercalated ducts to force it to secrete desmosomes hold them in position |
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intercalated ducts
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secretions flow into here from the lumen
brings it to the secretory duct simple cuboidal Lies in lobules |
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Secretory ducts
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Receives secretions from intercalated ducts
Brings it to excretory ducts basal striations that represents accumulations of mitochondria due to Na transporters modifies the contents of the saliva Simple columnar Lies in lobes |
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Excretory ducts
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stratified squamous
Surrounded by CT Receives secretions of secretory ducts Brings to oral cavity |
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Pilocarpine
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drug used to promote salivary flow
increase HR and BP |
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Which gland does not have serous alveoli?
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Sublingual gland
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What gland is the prime location to develop stones?
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Submandibular gland
More prone to stones because of anatomy and viscous secretions |
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What are the clinical signs of submandibular stone development/
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Swollen hard nodule under the mandible
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Mucocele
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Minor salivary gland has been damaged/blocked
Prevents secretion into duct and instead secretes in surrounding tissue creating bubble/swelling Mucin is released causing inflammation |
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What are the clinical signs of Mucocele?
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Large mucous like swelling on lip or bottom of tongue
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Sjogren's syndrome
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autoimmune condition that affects major salivary glands
Bilateral swelling of parotid glands seen not painful but has dry eyes, mouth and skin |
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What are the clinical signs of Sjogren’s syndrome
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Bilateral swelling of parotid glands
not painful but has dry eyes, mouth and skin |
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What are the problems with saliva substitutes?
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They are viscous but not visco-elastic therefore it cannot attach to surface of mucosa and enamel
Visco-elasticity comes from Mucin |
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sIgA
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general antiviral and antibacterial agent
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Cystatin
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Antiviral (Anti HIV), antifungal
has crystal growth inhibition |
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histatins
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antifungal
has crystal growth inhibition |
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Mucosal Pellicle
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protect against mechanical insult and for lubrication
Attracts water to create a physical barrier |
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crystal growth inhibitors
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Salivary proteins prevent Ca-P to precipitate out of solution
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enamel pellicles
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Inhibitory proteins on teeth to prevent additional Ca-P crystal growth on enamel
Ca-P can penetrate through hypomineralized enamel because saliva is not present |
