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25 Cards in this Set

  • Front
  • Back
Productive Cough
Productive cough (“loose”, “chesty”, “wet”)

Productive coughs are coughs that expel:
lower respiratory tract secretions; common conditions associated with productive coughs include bacterial pneumonia, bronchitis, COPD, asthma.

• “effective” productive coughs – secretions easily expelled

• “ineffective” productive coughs – secretions present but difficult to expel
NonProductive Cough
Nonproductive coughs are coughs that do not expel lower respiratory tract secretions; common conditions associated with nonproductive coughs include viral lower respiratory tract infections, some atypical pneumonias (e.g., Mycoplasma pneumoniae), GERD, cardiac disease, and drugs.
Acute Cough
Define: < 3 weeks

Ex: Upper respiratory tract infections (e.g., common cold), lower respiratory tract infections (e.g., pneumonia), pulmonary emboli, heart failure, asthma exacerbation, COPD exacerbation
Sub-Acute Cough
Define: 3-8 weeks

Ex: Postinfectious (pneumonia, pertussis, bronchitis), new or worsening upper airway cough syndrome (UACS), asthma, bronchitis, GERD
Chronic Cough
Define: > 8 weeks

Ex: Most common: UACS (including postnasal drip), asthma, GERD
Other: left-sided heart failure, bronchogenic carcinoma, aspiration secondary to pharyngeal dysfunction; drugs
Identify common diseases associated with cough
-Upper airway cough syndrome
-Common cold
-Asthma
-GERD
-Bronchitis
-Bronchiectasis
-Post-infectious
-Lung Tumors
-Oropharyngeal dysphagia
-ACE inhibitors
-Habit cough and psychogenic cough
-Chronic interstitial pulmonary disease
-Occupational and environmental
-Tuberculosis and other infections
-Peritoneal dialysis-associated cough
State the indications for cough suppressants
American College Codeine and Dextromethorphan are not recommended for coughs associated with UACS or the common cold
State the indications for cough expectorant
American College of Chest Physicians 2006: Guafenesin is not recommended for any indication
American College of Chest Physicians 2006 Evidence Based Guidelines
1. Codeine and dextromethorphan are not recommended for coughs associated with UACS or the common cold.

2. Guaifenesin (glyceryl guaicolate) is not recommended for any indication.

3. Antihistamine monotherapy is not recommended for any indication.

4. Benzonatate is not recommended for any indication.

5. Children (<15 years of age) – “In children with cough, cough suppressants and other OTC cough medications should not be used as patients, especially young children, may experience significant morbidity and mortality.”
“Cough should be treated based on etiology, and there is no evidence for using medication for the symptomatic relief of cough.” [From the 2006 ACCP Cough Guidelines]
Cough Self-Exclusions
• hemoptysis
• significant shortness of breath
• post-endotracheal intubation
• coughs persist >7-10 days despite self-tx
• all coughs >3 weeks duration
• coughs associated w/ new symptoms
• coughs that worsen during treatment
• coughs associated w/ foreign body aspiration
• pleuritic chest pain
• fever >101.5F >3 days
• coughs productive of thick yellow or
• drenching night sweats, green sputum
• drug-associated coughs
• coughs a/w acute asthma exacerbations
Humidifiers
Add water to the air; ultrasonic, impeller, evaporative; cool mist, steam (caution – increased humidity increases molds and dust mites which may worsen allergies; also disperses minerals and microorganisms into air). Steam humidifiers may burn or scald if tipped over. Change water daily, use distilled or demineralized water, clean every three days, and change filter regularly; keep humidity 30-50% and keep surrounding area dry.
Vaporizers
Humidifiers with a medication cup or well. Waterless vaporizers available.
Upper Airway Cough Syndrome
TYPE OF COUGH: Chronic

DRUG THERAPY: 1st generation antihistamine and decongestant combination4

QUALITY OF EVIDENCE: Low

NET BENEFIT: Intermediate

STRENGTH: Weak
Common Cold
TYPE OF COUGH: Acute

DRUG THERAPY: 1st generation antihistamine and decongestant combination4

QUALITY OF EVIDENCE: Fair

NET BENEFIT: Substantial

STRENGTH: Strong
Acute bronchitis
TYPE OF COUGH: Acute

DRUG THERAPY: 1st generation antihistamine and decongestant combination4

QUALITY OF EVIDENCE: Fair

NET BENEFIT: Small/Weak

STRENGTH: Weak
Chronic bronchitis
TYPE OF COUGH: Acute

DRUG THERAPY: Codeine, Dextromethorphan6

QUALITY OF EVIDENCE: Fair

NET BENEFIT:Intermediate

STRENGTH: Moderate
Postinfectious
TYPE OF COUGH: Sub-Acute

DRUG THERAPY: Codeine, Dextromethorphan6

QUALITY OF EVIDENCE: Expert Opinion

NET BENEFIT: Intermediate

Strength: Expert Opinion Only/Moderate
Lung tumors
TYPE OF COUGH: Chronic

DRUG THERAPY: Dihydrocodeine, Hydrocodone

QUALITY OF EVIDENCE: Low

NET BENEFIT: Intermediate

Strength: Weak
Guaifenesin
(Humibid) OTC,Rx
-Expectorant
-200-400mg every 4hrs
-dosage forms: syrups, liquids, tablets, SR tablets
-Gastrointestinal upset
-Hypersensitivity
benzonate (Tessalon) Rx
-Local Anesthetic
-100mg TID
-capsules
-Drowsiness, constipation, gastrointestinal upset
-"caine" allergies
codeine (various) OTC, Rx
-Central Suppressant
-10-20mg every 4-6hrs
-solutions,syrups
-Drowsiness, gastrointestinal upset
-Hypersensitity, MAOI
dextromethorphan (Hold DM) OTC
-Central Suppressant
-10-30mg every 4-6hrs
-syrups, liquids, ER suspension, gelcaps, ODS, oral spray, losenges
-Drowsiness, gastrointestinal upset
-Hypersensitivity, MAOIs
diphenhydramine (Benadryl) OTC, Rx
-Central Suppressant
-25mg every 4hrs
-syrups, liq., ODS
-Drowsiness, Mucosal drying
-Prostatic hypertrophy, asthma, glaucoma
State the requirements for OTC sale of Schedule C-V codeine-containing cough products.
Codeine OTC: Schedule C-V max 200 mg codeine per 100ml and at least one noncodeine active ingredient. Check individual state laws.
FDA-Approved Cough Therapies (Topical)
• Camphor (4.7-5.3%) & menthol (2.6-2.8%) topical ointments; OTC
• Camphor/menthol patch; OTC BID
• Menthol lozenges 5 –10 mg; OTC PRN
• Camphor (6.2%) & menthol (3.2%) for steam inhalation