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7 Cards in this Set
- Front
- Back
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What are the composition of connective tissue?
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cells, fibers, ground substance PLUS extracellular matrix (ECM)
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BACKGROUND INFO ON ECM
In the extracellular matrix, what are the three major types of proteins and their compositions? |
1) Glycoproteins
* fibronectin *laminin- restricted to the basal laminae *Osteopontin= bone, calcium binding. 2)Proteoglycan- looks like bottle brush made from glycosaminoglycans (GAGs- branches of brush) binding to Hyaluronate. *negative charge and holds alot of water. 3) Fibrilla proteins -collagen fibers -reticular fibers -elastic fibers * |
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What is the function of collagen and what are the two types?
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Function: provides tensile strength
1) Fibrillar collagen 2) Nonfibrillar collagen - (ONLY FOUND IN BASAL LAMINA!) |
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What is tropocollagen?
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formed of 3 alpha collagens chains.
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How does collagen type I formed?
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preprocollagen (pro alpha chain) have registration peptide attached to it for the critical alignment of alpha chain into helix and prevent premature fiber forming inside cell. Once a helix, progress to exocytosis from the cell. Rest of the steps take place outside cell. Cannot be inside else cell will BURST due to size of fibers. Once outside, procollagen activates enzyme to snip the registration peptide off either end for the formation of the mature tropocollagen
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MACROPHAGES
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DESCRIBE WHAT YOU KNOW ELSE LOOK IN BOOK
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MAST CELS = BASALPHILLIC, WILL STAIN BLUE
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Simialr to macrophages
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