Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Warfarin
|
Inactivates Vitamin K epoxide reductase (vitamin k recycling)
Oral Monitor with INR (PTtest/PTnormal) Between .8-1.2 Slow onset Polymorphism -Dynamics; enzymes ability to be inhibited (least effective in African Americans) -Kinetics; 2C9 function Not used during pregnancy ADR: Tissue necrosis (bridge with Heparin), osteoperosis Antagonism; Vitamin K (slow) Fresh Frozen Plasma (fast) |
|
|
Heparin
|
Potentiates ATIII -> decrease Factor X activity
IV/SC Monitor with PTT (HMWH) or Factor X function LMWH) Quick onset Used during pregnancy ADR: H.I.T (treat with Direct Thrombin Inhibitors) and osteoperosis Antagonism; Protamine (less effective with LMWH) |
|
|
Factors Decreasing Platelet Aggregation
|
cAMP/cGMP
Adenosin NO Prostacyclin |
|
|
Factors Increasing Platelet Aggregation
|
Thrombin
Serotonin TXA2 Platelet Aggregating Factor ADP Adrenaline |
|
|
Direct Thrombin Inhibitors
|
-rudin/-gatran
Lepirudin Desirudin Bivalirudin Argatroban Ximelagatran -> metabolized to active Melagatran Dabigatran (many drug interactions) |
|
|
Anti-platelet Drugs: COX-I
|
Aspirin
|
|
|
Anti-platelet Drugs: P2Y12 (ADP) Receptor Blockers
|
Thienopyridines; used when Aspirin is contraindicated
-Ticlopidine -Clopidogrel; pro-drug, requires liver metabolism -Prasugrel; pro-drug, requires liver metabolism -Ticagrelor; not a pro-drug |
|
|
Anti-platelet Drugs: GP IIb/IIIa Blockers
|
Abciximab
Eptifibatide Tirofiban *all given IV |
|
|
Adenosine Reuptake Inhibitor
|
Dipyridamole
|
|
|
Plasminogen Activators
|
Streptokinase - uncomplexed plasminogen activation
Alteplase (r-TPA) - activates only fibrin bound plasminogen (clot specific) Break up Fibrin clots *always coadminister with aspirin *Treat OD with Aminocaproic Acid |
