Coagulation

Front 1

Does not require vitamin K to its production by the liver?

Not a serine protease?

Classic hemophilia?

Back 1

Factor VIII

Front 2

Precursor of thrombin?

Coag family that is dependent on vitamin K synthesis?

Back 2

Prothrombin

Front 3

Fibrinogen is converted to fibrin by?

Back 3

Thrombin

Front 4

Acts on fibrin?

Back 4

Plasmin

Front 5

End result of most coag test?

Back 5

Fibrin clot

Front 6

Prothrombinase complex.

Back 6

Xa-Va-phospholipid-calcium

Front 7

*Origin of platelets in the bone marrow?

Back 7

Megakaryocytes

Front 8

Low platelet count & normal bleeding time.

Back 8

Autoimmune thrombocytopenia

Front 9

Normal range of direct platelet count?

Back 9

140,000 - 440,000 / uL

Front 10

*Bleeding tendency.

Back 10

50,000/uL

Front 11

Quantitative defect of platelets is known as?

Back 11

Thrombocytopenia

Front 12

*Thrombocytopenia?

Back 12

Prolonged bleeding time

Front 13

Thrombocythemia?

Back 13

Platelets are markedly increased

Front 14

Factor VIII is present in highest concentration.

Back 14

Cryoprecipitate

Front 15

Prolonged bleeding time with normal platelet count?

Back 15

Aspirin digestion

Vascular abnormality

vW syndrome

Front 16

Test that uses a reagent form of tissue thromboplastin.

Back 16

Prothrombin time

Front 17

*Phase contrast microscope

Back 17

Brecker cronkite

Front 18

If PT is abnormal, APTT is normal?

Back 18

Factor VII

Front 19

If PT is normal, APTT is normal?

Back 19

Factor VIII

Front 20

Bleeding time, PT - NORMAL

APTT - ABNORMAL

Back 20

VIII

Front 21

Only test that is sensitive to a deficiency of factor VII?

Back 21

Prothrombin time

Front 22

APTT serves as a screening procedure for?

Back 22

All except VII and XIII

Front 23

5M urea of 1% monochloroacetic acid.

Back 23

XIII

Front 24

Diagnosis of von Willebrand’s disease

Back 24

Decreased VIII:C

“ VIIIR:RCo

Prolonged bleeding time

Front 25

Occur in the alternate pathway?

Back 25

Factor VIIIa, can activate IX & X

Factor IX & kallikrein can activate factor VII

Factors XIIa, Xa, IXa or thrombin can activate VII

Front 26

Principle inhibitor of thrombin & factor Xa

Back 26

AT-III

Front 27

*Degrades factors Va & VIIIa

Back 27

Protein C

Front 28

*Accelerates inactivation of factors Va & VIIIa

Back 28

Protein S

Front 29

*Inhibits vitamin K

Back 29

Coumadin

Front 30

Inactivates zymogen, binds fibrin ay critical lysine binding sites

Back 30

Plasminogen

Front 31

Greatly enhances activity of AT-III

Back 31

Heparin

Front 32

Activates plasminogen for lysis if thrombi

Back 32

Streptokinase

Front 33

Inactivates coag factors through phospholipoprotein components.

Back 33

Lupus-like anti coagulant

Front 34

*Fibrinogen has to decrease below what level to affect the various clotting test?

Back 34

75 mg/dL

Front 35

Increased platelet destruction?

Back 35

Idiopathic thrombocytopenic purpura

Front 36

DIC is associated with?

Back 36

Snake bites

Placenta praevia

Acute granulocytic leukemia or acute monocytic leukemia

Front 37

*Results of patient with DIC?

Back 37

⬇️ plts & factors 1,5,8

Prolonged PT, APTT & TT

Positive D-dimer

Front 38

*Ehlers Danlors, vW & Bernard Soulier are all qualitative platelet disorders that have abnormalities of

Back 38

Adhesion

Front 39

*Qualitative platelet disorder that has abnormal primary aggregation.

Back 39

Glanzmann

Front 40

Storage pool deficiency & Wiskott- Aldrich are qualitative platelet disorder that have abnormal

Back 40

Secondary aggregation

Front 41

Qualitative Platelet Disorders

Back 41

Storage pool deficiency

Wiskott - Aldrich

Glanzmann

Ehlers Danlos

von Willebrand

Bernard Soulier