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10 Cards in this Set
- Front
- Back
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Colchicine |
Gout Binds to tubuline molecules to stop polymerization of microtubule. Purpose is to inhibit migration of neutrophil cells to avoid responding to urate crystals |
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Vinblastine & vincristine |
Cancer therapy Binds to microtubule to stop mitotic spindle formation to arrest cancer cell division |
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Paclitaxel (Taxol) |
Cancer therapy stop depol and stabilizes microtubule to prevent cancer cell from dividing |
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Defect in microtubule organization and its associated proteins; immobilize cilia |
Kartagener's Syndrome Accumulation of sectetion Low sperm count Infertility in women |
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Cytochalasin B, D |
Binds to (+) end of actin to stop polymerization; inhibits cell migration, phagocytosis and cell division |
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Phalloidin |
Binds to actin filaments to stabilize and prevent depol; used to stain actin |
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Produces neurofibrillary tangles containing neurofilaments and other microtubule-associated proteins |
Alzheimers Dse |
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Alexander Dse |
Mutation of GFAP gene. Presence of Rosenthal fivers- accumulation of GFAP and other proteins in Astrocytes which prevents assembly Children-leukoencephalopathy, Macrocephaly, seizures,psychomotor impairement, death within 1st decade |
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Prominent feature of Alcoholic Liver Cirrhosis |
Mallory Bodies- presence of keratin intermediate filaments |
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Aneuploidy caused by? |
Multipolar cell division which results in cell death |
