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24 Cards in this Set
- Front
- Back
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features of regenerative anemia |
appropriate marrow response blood loss or hemolysis macrocytic, hypochromic, (normochromic) polychromasia/reticulocytosis mild to marked |
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breeds that normally have a macrocytosis |
poodles sight hounds |
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Blood loss can be |
external or internal not always obvious |
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features of external blood loss |
RBC lost to the body no recycling |
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features of internal blood loss |
recycling autotransfusion most commonly get hemothorax or hemoabdomen |
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why might a regenerative anemia look like a non-regenerative anemia |
If CBC is taken too early then there will not have been enough time for polychromatophils to be created so none will be present as in non-regenerative anemia |
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raw materials needed for erythropoiesis |
heme (including Fe) gobin chains many enzymes |
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what breeds normally have a microcytosis |
Asian breeds (akita, shiba inu, etc..) |
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iron deficiency anemia |
mild to marked microcytic, hypchromic (almost only thing that causes this) inadequately regenerative |
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pathophysiology of iron deficiency anemia |
chronic external blood loss causes iron loss from body No Iron for Hgb synthesis causes inadequately regenerative anemia RBC precursors undergo additional divisions causing microcytosis RBCs have less Hgb so have hypochromasia |
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RBC morphology and lifespan with Fe-dfieiciency |
lifespan decreased because RBCs more fragile May see keratocytes and schizocytes |
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schizocytes |
fragments of RBCs Irregularly shaped, with jagged edges and two pointed ends |
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Keratocytes |
RBC with a blister like vesicle Vesicle may rupture leaving a bite shaped defect in cell membrane (look like one or two horns sticking off) |
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platelet count with Fe-deficiency |
thrombocytosis (increased)
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Detecting Fe-deficiency anemia |
decreased serum Fe increased transferrin decreased ferritin and hemosiderin |
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which species may you not see an increase in transferrin in with Fe-deficiency |
dogs |
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function of ceruloplasmin |
role in iron transport Needs a copper |
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Cu-deficiency anemia pathophysiology |
Decreased Cu means decreased ability to use Fe functional Fe-deficiency Total body Fe still adequate |
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features of Cu-deficiency anemia |
microcytic hypochromic inadequately regenerative |
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anisocytosis |
RBCs are of unequal size in circulation |
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acanthocyte |
RBC with a spiky cell membrane |
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nuclear remnants |
the small pieces of nucleus that get left behind when macrophages clean up old RBCs |
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corrected white blood cell count |
more accurate than just WBC count because it does not count nucleated RBCs which are included in WBC count |
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NRBC |
nucleated red blood cell part of the regeneration process |
