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16 Cards in this Set
- Front
- Back
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Prevalence chronic pancreatitis |
30/100,000 |
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Annual incidence chronic pancreatitis |
3.5-10/100 000 |
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Radiates to mid-back, scapula, increases 30mins post-prandial, eased by sitting forwards |
Abdominal pain characteristics in chronic pancreatitis |
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Abdominal pain, large duct chronic pancreatitis |
Ductal hypertension |
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Abdominal pain, small duct pancreatitis |
Neural injury |
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Reflects injury atrophy and loss of exocrine tissue due to inflammation and fibrosis of gland |
Explains steatorrhoea and azotorrhoea in chronic pancreatitis |
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Proportion of chronic pancreatitis sufferers with associated vitamin D deficiency |
53% |
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Independent, dose-dependent risk factor for chronic pancreatitis. Inhibits exocrine secretion of HCO3- and fluids |
Smoking |
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Mutations in serine protease 1 PRSS1, serine protease inhibitor SPINK1, cystic fibrosis transmembrane conductance regulator CFTR |
Genetic factors in pathogenesis of chronic pancreatitis |
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Paracetamol, ibuprofen, tramadol, somatostatin analogue |
Analgesics in chronic pancreatitis |
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Pancreatin and omeprazole |
Pancreatic enzymes and PPI to prevent denaturing them, prevents malabsorptive states |
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Fibrosis, atrophy, ductal stenosis, ductules filled with thickened secretions or calculi, ductal stones |
Macroscopic pathological features of pancreatitis |
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Loss of acini, dilatation of ductules, fibrosis, lymphocyte infiltration CD4+ CD8+ cells |
Microscopic pathological features of pancreatitis |
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Dilate dmain pancreatic duct, secondary to obstruction due to calculi |
Large duct disease, chronic pancreatitis |
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Atrophic acini, calcifications without focal ductal abnormality or dilatation |
Small duct disease chronic pancreatitis |
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Poor delivery digestive enzymes to duodenum, decreasing HCO3- with resulting gastric acid activating enzymes and bile acids, gastric dysmotility and mechanical obstruction from fibrosis in head of pancreas |
Pancreatic insufficiency |
