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3 Cards in this Set
- Front
- Back
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Causes |
Alcohol Autoimmune Pancreatic duct obstruction- stricture, stones, tumour. Anatomical abnormalities - pancreatic divisum. Genetic - SPINK1 Tropical pancreatitis. |
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Pathophysiology |
Intraductal plugging & obstruction Direct toxins & metabolites - act on pancreatic acinar cells to stimulate cytokine release —> stimulate stellate cells to produce collagen & fibrous tissue. Cytokines also stimulate inflammation by neutrophils, macrophages & lymphocytes. Oxidative stress - eg. Idiopathic pancreatitis Necrosis-fibrosis - recurrent acute pancreatitis healing with fibrosis Ischaemia - from obstruction & fibrosis |
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Treatment |
Stop offending habit (etoh) Analgesia - involve CPS Steatorrhea - creon Diabetes - insulin Still not working —> surgery (Puestow/Frey) |
