Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
alkylating agents
: method : examples : common side effects |
: alkylate DNA, crosslink strands or break
: methochlorethamine (mustard gas), cyclophosphamide (hemorrhagic cystitis), dicarbazine, procarbazine, cisplatin. : n/v, BM |
|
|
antibiotics
: method : examples : common SE |
: from fungus. go inbetween DNA and uncoil
: doxorubicin, daunorubicin, bleomycin, dactinomycin (hem cystitis) ; |
|
|
Epidophyllotoxins (plant derived
: method : examples : SE |
: inhibit Topo II by permanently binding DNA to Topo.
: etoposide : MB, n/v, hypersensitivty, neuropothy |
|
|
Vinca Alkyloids
: method : example : SE |
: inhibits microtubular formation-->no spindle
: vincristine, vinblastine, vinorelbine : neurotoxic |
|
|
Taxanes
: method : examples : SE |
: over abundance of microtubes.
: paclitaxel, docetaxel : BM, hypersensitivity, neuropathy |
|
|
camptothecins
: method : examples : SE |
: Inhibit topo I--> DNA strand breakage.
: irinotecan, topotecan. : BM |
|
|
Methotrexate
: method : SE |
: inhibits dihydrofolate reductase, no purines.
: BM, n/v, liver dysfunction. : leukemia |
|
|
Fluorouracil (5-FU)
|
: inhibit thymidylate syntetase, inhibit RNA synthesis
: BM, GI, handfoot syndrome |
|
|
Gemcitabine
|
: gets into DNA chain, results in elongatin?
: melosupression, fever |
|
|
hydroxyurea
|
: inhibits ribonucleotide reductase.
: BM depression |
|
|
tamoxifen
: method : examples : SE |
: binds to estrogen receptors
: breast cancer |
