Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/11

Click to flip

11 Cards in this Set

  • Front
  • Back
alkylating agents
: method
: examples
: common side effects
: alkylate DNA, crosslink strands or break
: methochlorethamine (mustard gas), cyclophosphamide (hemorrhagic cystitis), dicarbazine, procarbazine, cisplatin.
: n/v, BM
antibiotics
: method
: examples
: common SE
: from fungus. go inbetween DNA and uncoil
: doxorubicin, daunorubicin, bleomycin, dactinomycin (hem cystitis)
;
Epidophyllotoxins (plant derived
: method
: examples
: SE
: inhibit Topo II by permanently binding DNA to Topo.
: etoposide
: MB, n/v, hypersensitivty, neuropothy
Vinca Alkyloids
: method
: example
: SE
: inhibits microtubular formation-->no spindle
: vincristine, vinblastine, vinorelbine
: neurotoxic
Taxanes
: method
: examples
: SE
: over abundance of microtubes.
: paclitaxel, docetaxel
: BM, hypersensitivity, neuropathy
camptothecins
: method
: examples
: SE
: Inhibit topo I--> DNA strand breakage.
: irinotecan, topotecan.
: BM
Methotrexate
: method
: SE
: inhibits dihydrofolate reductase, no purines.
: BM, n/v, liver dysfunction.
: leukemia
Fluorouracil (5-FU)
: inhibit thymidylate syntetase, inhibit RNA synthesis
: BM, GI, handfoot syndrome
Gemcitabine
: gets into DNA chain, results in elongatin?
: melosupression, fever
hydroxyurea
: inhibits ribonucleotide reductase.
: BM depression
tamoxifen
: method
: examples
: SE
: binds to estrogen receptors
: breast cancer