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7 Cards in this Set
- Front
- Back
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levodopa-carbidopa (Sinemet) |
Dopamine replacement
Indications: control symptoms of Parkinson’s. Carbidopa isn’t used to treat symptoms, but the nausea associated with Sinemet
Usual dose: anywhere from 3-8 times a day, others at 4-8 hour intervals
Adverse effects: GI effects, nausea
Contraindications: angle closure glaucoma, undiagnosed skin condition because can cause malignant melanoma
Interactions: tricyclic antidepressants, antipsychotics, nonselective MAOIs, benzodiazepines (antipsychotics)
Administration: best taken on an empty stomach but can be taken with food to prevent GI upset. Sinemet CR cannot be crushed but can be split one time |
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selegiline (Eldepryl) |
Indications: Parkinson’s, adjunct for levodopa
Usual dose: 5 mg bid w/ breakfast and lunch
Adverse effects: weight loss, GI upset, back pain, impulse control disorders, headache, confusion
Contraindications: meperidine, allergy
Interactions: tyramine containing foods, meperidine
Administration: can be used with levodopa or monotherapy |
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ropinirole (Requip) |
Nonergot NDDRA
Indications: early and late stage Parkinson’s, restless leg
Usual dose: 0.25 mg tid, slowly increasing to max dose of 24 mg/day
Adverse effects: dizziness, GI upset, somnolence
Contraindications: allergy
Interactions: any drug metabolized by cytochrome P-450 enzyme 1A2
Administration: oral use only, delay the need for levodopa therapy |
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amantadine (Symmetrel) |
Dopamine modulator
Indications: influenza virus infections, mild to moderate Parkinson’s
Usual dose: 100-400 mg/day divided every 12 hrs
Adverse effects: dizziness, insomnia, nausea
Contraindications: allergy
Interactions: anticholinergics
Administration: oral use only |
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benztropine (Cogentin) |
Anticholinergic
Indications: Parkinson’s, extrapyramidal symptoms from antipsychotics
Usual dose: 0.5-6 mg/day
Adverse effects: hyperthermia, tachycardia, confusion, disorientation, toxic psychosis, urinary retention, dry mouth, nausea
Contraindication: use with caution in hot weather and exercise
Interactions: alcohol, other drugs with anticholinergic effects
Administration: tablets and injectable |
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tolcapone (Tasmar) |
COMT inhibitor
Indications: Parkinson’s
Adverse effects: sever liver failure, GI upset, urine discoloration, worsened dyskinesia
Contraindications: allergy, liver failure
Interactions: no selective MAOIs
Administration: rarely used |
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entacapone (Comtan) |
COMT inhibitor
Indications: Parkinson’s
Usual dose: 200 mg with each levodopa dose, max of 1600mg/day
Adverse effects: GI upset, dyskinesia, urine discoloration
Contraindications: allergy, liver disease
Interactions: nonselective MAOIS
Administration: oral use, available in combination tablets |
