Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
Proteinopathy |
Altered protein conformations, interactions and homeostasis Common feature in of many neurodegenerative diseases |
|
|
prion hypothesis |
The infectious scrapie agent is proteinaceous in nature. Considered hierarchical |
|
|
Huntington’s disease |
Dominantly inherited disease that usually stokes patients during midlife, includes depression and mood swings and abnormal movements |
|
|
Amyotrophic lateral disease |
Aka Lou Gehrig disease A rapidly progressing motor neuron disease that kills patients within a few years after symptoms start |
|
|
Parkinson’s disease |
Second most common neurodegenerative disease Primarily affects movement control (shaking, rigidity, slowness and difficulty walking) |
|
|
Lewy bodies |
Intracellular inclusions that have been a defining feature of PD pathology |
|
|
Catecholamines |
A class of molecules that includes the neurotransmitter dopamine, norepinephrine and epinephrine |
|
|
Tyrosine hydroxylase |
A rate limiting enzyme in the biosynthesis of catecholamines Catalyses the conversion of L-tyrosine to L-dopa. |
|
|
Bipolar disorder |
Swing between manic and depressive phases |
|
|
Major depression |
Only the depressive stage and is more common than bipolar disorder |
|
|
Drug addiction |
A compulsive drug use despite long-term negative consequences |
|
|
Nucleus accumbens |
Best known for processing reward information One of the major output targets of VTA dopamine neurons |
|
|
Prefrontal cortex |
The second major output target of VTA dopamine neurons Responsible for executive function |
|
|
Intellectual disability |
Characterized by deficit in general mental abilities such as reasoning, problem-solving, planning, abstract thinking etc. |
