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23 Cards in this Set
- Front
- Back
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Axel Hillmer 2005
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Observed Pattern baldness
x-chromosome hypothesis conducted Linkage analysis study |
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Linkage Analysis Study
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inheritance of genetic variants known to be on X chromosomes
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SNPs aka Single Nucleotide polymorphism
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Positions in the genome where individuals vary in a single nucleotide = genetic variants
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Recombination
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breakdown of linkage b/w genes
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Amount o/Recombination
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amount of recombination b/w genes is directly related to the distance between them
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Whose method did Hillmer uses for his pattern baldness experiment?
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Thomas Hunt Morgan and Alfred Sturtevant : demonstrated genes that can be mapped by determining the recombination b/w genes
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Principle of segregation
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each individual diploid organism possesses 2 alleles for a charcteristc, each at the same loci on each chromosoome
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Principle of independent assortment
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processes of segregation where the alleles at a locus act independent of alleles at other loci
9:3:3:1 |
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Independent separation of alleles results in recombination
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sorting of alleles into new combinations
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Walter Sutton , 1903
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Chromosome theory of heredity
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Linked genes
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genes located close together on the same chromosomes; belong to the same linked group and are inherited together
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Cross over
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genes switched b/w homologous chromosomes
Prophase 1 of Meiosis |
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Complete linkage
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genes located close together and do not cross (rare)
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What is a test cross?
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Illustration of the effects of linkage
traits appearing in progeny reveal which alleles were transmitted. |
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Nonrecombinant (parental) gametes
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contain only original combinations of alleles present in the parents
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Recombinant gametes
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new combinations of alleles
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Recombination frequency
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percentage of recombinant progeny produced in a cross
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What's the Chi-Square equation?
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χ^2 = Σ (# observed - # expected)^2/(# expected)
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Coupling/cis configuration
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arrangement where wild type genes are found on 1 chromosome and mutant on the other
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Repulsion Configuration
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each chromosome contain one wild type and one mutant
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Interchromosomal recombination
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genes located on different chromosomes `
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intrachromosomal recombination
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interaction b/w genes on the same chromosome
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How can a 3 point test cross be used?
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Map three linked genes
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