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24 Cards in this Set
- Front
- Back
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Types of retrovirusis according to medical importance |
Lentiretrovirusis Deltaretroviusis |
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Major cause of AIDS worldwide يولاد |
HIV1 |
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Mutation of env gene gp 160 |
Lead to production of various types of gp 120 |
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Mediate the virus binding to host cell |
gp120 |
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Mediates the fusion of viral envelope to host cell membrane |
gp 41 |
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Pol gene |
Reverse transceptase enzyme Protease enzyme Integrase enzyme |
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Mechanisms of killing of infected cd4 T cells. |
1-directly by viral replication 2- by CD8 cytotoxic T lymphocytes |
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Provirus |
HIV DNA when become integrated ti host DNA |
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Factors determines the length of clinical latency |
1- type of virus 2- the immune response 3- administration of antiviral drugs |
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Examples of conditions where there is false +ve ELISA |
Syphilis Systemic lopus erythematosus |
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Window period |
From 3-4 weeks after infection |
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Viral load of HIV can be detected by |
RT PCR for RNA |
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Detection of p24 in patient serum denotes |
Early infection Or Late infection ▶️ poor prognosis |
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True or false : p24 can be detected by ELISA in window phase |
True |
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What is the most potent antiretroviral drug? |
Protease inhibitor |
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HAART |
Combination bw 2 reverse transcriptase inhibitors and 1 proteas inhibitor |
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Monitoring of anti-HIV therapy done by |
1-viral load detection (RT PCR) تبع ال rna 2- CD4 count |
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Post exposure chamoprophylaxis |
Start within 2 hours 2to3 antiviral to 28 days |
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Method of preventing vertical transmission |
Ttt of infected mothers during pregnancy Casarean section Ttt of neunates No breast feeding |
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Why some types of cancers occures in AIDs patients |
Due to immune dificiency |
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Major clinical manifestation of AIDs patient |
Wight loss Diarrhoea Neurological manifestations |
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Ttt of hiv infection |
HAART Combination bw 2 revirse trascriptase and one protease |
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Hiv post expusure chemoprophelaxis |
Start within 2 hours 2 - 3 antiviral drugs for 28 dyas |
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True or false: there is viremia early stage of HIV |
True |
