Ch.15 Pathogenicity

Front 1

Pathogenicity

Back 1

The ability to cause disease

Front 2

Virulence

Back 2

The extent to which a disease can be caused by the m/o

or the extent of pathogenicity

Front 3

Virulence Factors

Back 3

Properties that control the virulence (extent of disease) of an organism, and make it virulence

Front 4

To cause a disease... a bacterium must:

Back 4

[G.A.A.D]

1) Gain entry into the host body
2) Adhere to the host tissue
3) Avoid host's defense
4) Damage host's tissue

Front 5

Portals of entry into the host

Back 5

[ M. S. P. ]

1) Mucous Membrane
2) Skin
3) Parental Route

Front 6

Mucous Membrane Portal of Entry

Back 6

Respiratory Tract
GI Tract
Genitourinary Tract
Eyes

Front 7

Parental Route Portal of Entry

Back 7

When something s deposited DIRECTLY into tissues beneath the skin or mucous membrane through bites, burns, and injections

Front 8

ID50 (infectious dose)

Back 8

The infectious dose that causes infection in 50% of the test population

Front 9

LD50 (lethal dose)

Back 9

The amount of a toxin that is considered lethal for 50% of the test population

Front 10

4 Requirements for M.O for Establishment of Disease or Infection

Back 10

1) Enter the Organism
2) Adhere to the tissues
3) Penetrate the tissues
4) Damage cells to establish disease

Front 11

Adhesins/Ligands

Back 11

Surface molecules on pathogens that bind to the receptors on the host cells

ex: Glycocalyx, Fimbriae, m protein

Front 12

Glycocalyx

Back 12

Slime layer; an adhesive that helps bacteria such as Streptococcus mutans bind to the host

Front 13

Fimbriae

Back 13

Hair-like structure; an adhesive that helps E.coli bind to human urinary bladder cells

Front 14

M Protein

Back 14

helps Streptococcus pyogenes bind to host cell

Front 15

Biofilms

Back 15

A microbial community formed by some bacteria that forms a slime layer on a surface; help m.o attach to each other or the host's surface