Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
what are the endogenous fuels of the heart?
|
Triglycerides and glycogen
|
|
|
under resting positions, what are the proportions of fuel utilized by the heart?
|
Carbohydrate- 30 to 40
Fatty acids- 60 to 70 |
|
|
what is the randal cycle?
|
the variation in nutrients used by the heart between fasting and fed states
|
|
|
what happens to PDHC activity during the fasted state?
|
it is decreased due to inactivation by Acetyl-CoA
|
|
|
what happens to PFK activity during the fasting state?
|
it is decreased due to inactivation by citrate
|
|
|
what happens to HK in the fasting state?
|
it is inhibited by the accumulation of G6P.
this, in effect, decreases Glucose uptake |
|
|
what clinical conditions can be associated with high rates of Fatty acid oxidation?
|
angina
infarct diabetes post cardiac surgery |
|
|
how might you prevent a post ischemic dysfunction?
|
shift the hearts metabolism toward the utilization of glucose (oxidative)
|
|
|
why is diabetes bad for the heart?
|
insulin resistance/abscence results in FA metabolism in the heart
|
|
|
what type of fuel consumption does epinephrine promote?
|
FA metabolism
|
|
|
which drugs inhibit ketoacyl-CoA thiolase? (B-ox)
|
ranolazine
trimethizidine |
|
|
which drugs inhibit carnitine-palmitoyl transferase? (B-ox, FA uptake to Mito)
|
etomoxir
oxfenicine |
|
|
what drug stimulates PDHC?
|
dichloroacetate
|
