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23 Cards in this Set
- Front
- Back
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Cancer: alkylating agents
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-phase non-specific
-alkylate DNA and cross link |
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Cancer: antitumor antibiotics
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-some alkylate (mitomycin)
-others intercalate:sliding of molecule between DNA bases and inhibit synthesis |
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Cancer: antimetabolites
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-s-phase specific
-false substitution in the production of nucleic acids |
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Cancer: mitotic inhibitors
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-M-phase specific
-prevent microtubule formation (vincas) - promote microtubules and stabalize them -->no division (taxanes) |
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Cancer: topoisomerase inhibitors
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-G2 phase specific
-inhibits enzymes topoiso. I & II -these enzymes necessary for DNA replication and RNA transcription |
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Cancer: Enzymes
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-asparaginase: degrade essential asparagin. tumor cells cannot make asparagine.
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Cancer: Imatinib
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-tyrosine kinase inhibitor
-causes apoptosis in cells exhibiting bcr-abl protein (philadelphia chromosome) -all pts with CML have bcr-abl |
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Colony stimulating factors; role of
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-to increase neutrophil counts
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chemo with the most myelosuppression
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-carmustine
-cytarabine -daunorubicine -doxorubicine -paclitaxel |
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Chemo with NO myelosuppression
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-vincristine
-bleomycin -asparaginase |
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Chemo with most alopecia
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-cyclophosphamide
-doxorubicin -paclitaxel -mechlorethamine |
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Chemos as vesicants
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-anthracyclines
-vincas -mitomycin -dactinomycin |
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chemos with low emetogenic risk
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-vincas
-bleomycin -asparaginase -nib drugs -capecitabine |
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Chemos with most stomatitis
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-capecitabine
-5-FU -methotrexate |
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Chemos with the most lung toxicity
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-bleomycin
-busulfan -carmustine -mitomycin |
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Chemos with most cardiotoxicity
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-all rubicins
-mitoxantone |
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Cardioprotective drug used with anthracyclines
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-dexrazoxane
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Chemos with most anaphylaxis
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-asparaginase
-carboplatin -cisplatin -etoposide -paclitaxel -tenoposide |
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Chemo causing autonomic and peripheral neuropathies
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-vincristine
-never give IT ->fatal |
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Chemo causing peripheral neuropathy and ototoxicity
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-capecitabine
-oxaliplatine -paclitaxel |
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Which chemo can cause cerebellar toxicity
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cytarabine
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Chemo with most nephrotoxicity
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-cisplatin
-ifosphamide -mtx -streptozocin -IV hydration to reduce risk |
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Chemo with most hepatotoxicity
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-asparaginase
-cytarabine -6-MP -MTX |
