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28 Cards in this Set
- Front
- Back
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What is Amantadine?
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A lysosomotropic agent taken up by the cells into endosomes and prevents early events in orthomyxovirus replication
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How does Amantadine specifically stop influenza viral replication?
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Interferes with uncoating
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What are the side effects of Amantadine?
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Dydpepsia
Insomnia Influenza viruses become resistant |
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What does Zanamivix do?
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Inhibits spread of influenza virus on mucous membranes - NANAase
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What are the trick of antimetabolites?
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Resemble nucleic acid so get incorpotated instead of the rela nucleic acid
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What is IODO?
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A thymidine analog that inhibits DNA viruses
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What specifically can IODO be used for?
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Topically applied to the conjunctiva in herpes conjunctivitis
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What is Arabinose?
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An antimetabolite that is a purine analogue
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How does Arabinose inhibit DNA synthesis?
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Intereferes with the nucleotide phosphokinase
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What can topical Arabinose be used for?
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Genital and conjunctival herpesvirus infections
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What application type is required for Arabinose to treat enchephalitis or Hepatitis B?
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Systemic application
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How does Ribovirin work?
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Interferes with biosynthesis of Purines
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What can Ribovirin be used to treat?
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Hepatitis B and DNA viruses
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What is Acyclovir?
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A Guanosine analog
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What does Acyclovir do?
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Interferes with Herpesvirus replication
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What is AZT?
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Thymidine analog
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What does AZT do?
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Inhibits retrovirus replication
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How does AZT specifically inhibit retroviral replication?
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induces cDNA chain termination of reverse transcriptase
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When is AZT used?
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Chemotherapeutic agent in Lentiviruses to reduce viral load
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Which antimetabolites are teratogenic?
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Arabinose and Ribovirin
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What is crixivan?
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A protease inhibitor of viral stuctural protein processign
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What does Mytomycin C do?
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Inhibits replication of host cells and DNA viruses and retroviruses
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What does actinomycin D do?
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Inhibits nRNA transcription
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Which viruses are actinomycin D affective on?
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DNA viruses
Retroviruses |
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What was Rifampicin initially used to treat?
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Tuberculosis
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How does Rifampicin work?
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Modulates specificity for viral polymerases -
Retro Reo Rota |
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What do Puromycin/Cycloheximide do?
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Inhibit eukaryotic synthesis so viral proteins are not made in infected cells
DNA and RNA viruses |
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How do synthetic active sites of receptors work?
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They are synthetic stuructures that mimic receptor determinants and bind to virus ligands thus inhibiting infection of cells
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