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43 Cards in this Set

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  • Back
hyperplasia
increase in number of cells (reversible)
metaplasia
cell replaced but another cell type
dysplasia
abnormal growth with loss of cellular orientation, shape and size in comparison to normal tissue maturation; commonly preneoplastic
anaplasia
abnormal cells lacking differentiation; like primative cells of same tissue, often equated with undifferentiated malignant neoplasms
neoplasia
a clonical proliferation of cells that is controlled and excessive
anaplastic cells
increased N:C ratio
prominent nucleoli
nuclear chromatic clumping
many mitotic figures
tumor grade
based on histologic appearance of tumor
tumor stage
degree of localization/spread based on site and size of primary lesion, spread to regional lymph nodes, presence of mets
benign tumors
orderly growth, don't invade basement membrane, no mets, mature, well diff
malignant tumors
disorganized growht, might invade basement membrane, maybe mets, immature undiff
epithelial tumor spread
lymph
mesenchyme tumor spread
hematogenous
male cancer incidence
prostate, lung, colon and rectum
male cancer death
lung and prostate
female cancer incidence
breast, lung, colon and rectum
female cancer death
lung and breast
aflatoxins (from Asp mold)
hepatocellular carc
vinyl chloride
angiosarcoma
CCl4
centrilobular necrosis, fatty change
nitrosamines
esophagus, stomach
cigarette smoke
larynx, lung, bladder, cervical, pancr
asbestos
mesothelioma and bronchogenic
arsenic
sq cell carc
naphthalene (aniline) dyes
transitional cell carc
alkylating agents
leukemia
small cell lung carcinoma
ACTH-->Cushings
small cell lung carcinom and intracranial neoplasms
ADH --> SIADH
squamous cell lung carc, renal cell carc, breast carc, MM, bone mets
PTH related peptide, TGF-B, TNF-A, IL1-->hypercalcemia
renal cell carc, hemangioblastoma
EPO-->polycythemia
Thymoma, small cell lung carc
AB against presynaptic Ca channels at NMJ --> Lambert Eaton syndrome (improves with use)
leukemias and lymphomas
hyperuricemia due to excess nucleic acid turnover-->gout, urate nephropathy
mets to brain
lung, breast, melanoma, kidney, GI
mets to liver
lung, breast, colon, stomach, pancreas
mets to bone
lung, breast, thyroid, testes, prostate, kidney
HTLV1 virus
adult T cell leukemia
HBV, HCV
hepatocellular carc
EBV
burkitts, nasopharnygeal
HPV
cervical, penile, anal
HHV 8
Kaposis, body cavity fuild B cell lymphoma
S bovis
colon cancer
H pylori
gastric cancer
Schistosoma
bladder cancer
clonarchis senesis
biliary cancer