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108 Cards in this Set

  • Front
  • Back

Similar cells with common function come together to form

Tissues

Histology

Study of tissues

Tissues classified into 4 catagories

1. Epithelial


2. connective


3. muscle


4. nervous

Extracellular matrix (ECM)

produced by cells, water, protein fibers, dissolved molecules found in all tissues but at varying degrees.

Epithelial tissues

1. covers body surfaces


2. lines the body cavities


3. forms most of the glands


Characteristics of epithelial tissues

cellularity, polarity, basement membrane, avascularity, extensive innervation, and high regeneration capacity

Cellularity


Characteristics of Epithelial tissue

epithelial tissue composed of tightly packed cells, minimal amount of ECM


polarity


Characteristics of Epithelial tissue

epithelial tissues exhibits polarity, cells have an apical surface (exposed surface to open space) and a basal surface (surface attached to underlying connective tissue) additionally the lateral surface of cells are attached via junctions

Basement membrane


Characteristics of Epithelial tissue

epithelium is bound to basement membrane at its basal surface, consists of 3 layers: lamina lucida, lamina densa, reticular lamina, forms a selective barrier between epithelial tissue and underlying connective tissue

Avascularity


Characteristics of Epithelial tissue

epithelial tissue lack blood vessals, nutrients to epithelial tissue are provided directly via apical surface or by diffusion across the basal surface from the connective tissue

Extensive innervation


Characteristics of Epithelial tissue

richly innervated, must have the ability to detect environmental changes

High regeneration capacity


Characteristics of Epithelial tissue

ability to regenerate achieved by the stem cells of epithelial tissue located adjancent to the basement membrane

Function of epithelial tissue

Physical protection, selective permeability, secretions, sensations

Physical protection


Functions of Epithelial Tissue

protection of external and internal surfaces of dehydration, abrasion, and destruction by physical, chemical or biological agents

Selective permeability


Functions of Epithelial Tissue

any substance that enters or leaves the body must pass through epithelium serve as "gatekeepers", epithelium permeable to some substances and could be impermeable to others

Secretions


Functions of Epithelial Tissue

specialized epithelial cells have the ability to produce secretions and therefore can function as a unicellular gland or multicellular gland

Sensation


Functions of Epithelial Tissue

epithelium is highly innervated and has the ability to detect changes and convey this information via nervous system (touch, pressure, temp, and pain)

Can epithelial tissue be classified by number of cells layers or cell shapes

yes

Simple epithelium


Cell layers

one cell layer thick all cells are attached to basement membrane, found in areas where there is minimal stress and where filtration, absorption or secretion is primary function (lining of air sacs of lung, intestines, blood vessels

Stratified epithelium


Cell layers


two or more layers of epithelial cells, only deep layer in direct contact with basement membrane, found in areas exposed to abrasion, mechanical stress, cells in basal layer continuously regenerate as apical surface cells are damaged (skin, internal lining of pharynx, esophagus)

Pseudostratified epithelium


Cell layers


looks stratified because cells nuclei are distributed at different levels, all cells are attached to basement membrane therefore can be classified into simple epithelium

Squamous


cell shape

flat, wide, irregular shape, nucleus flattened

Cuboidal


Cell shape

Cube-like round edges, nucleus spherical and located in center of cell


Columnar


cell shape

slender and taller than wider, oval nucleus and located in basal side of cell

Transitional


cell shape

have the ability to change shape depending on how stretched the epithelium is if relaxed will have polyhedrant appearance and distended flattened cells


Simple squamous

single layer of flattened cells , extremely delicate and highly specialized to allow rapid movement of molecules via diffusion, osmosis, filtration, found in air sacs of lungs, lining of lymph and blood vessels (endothelium), serous membrane of body cavities (mesothelium)

Simple cuboidal

single layer of cells about as tall as they are wide, absorb fluids and other materials across its apical surface to secret substances, found in kidney tubules, ducts and secretory regions of glands, surface of ovary, thyroid gland follicles

Simple columnar

single layer of cells taller than wide, ideal for secretory and absorptive functions

Nonciliated simple columnar

absorption and secretion, often contains microvilli and unicellular glands termed goblet cells (secrete mucin) (digestive tract stomach to anal canal)

Ciliated simple columnar

secretion of mucin and movement of mucus, goblet cells present, oocyte movement through uterine tube, found in larger bronchioles of respiratory tract and lining of uterine tubes

Pseudostratified columnar

appears as multiple layers but not truly stratified because all cells are in direct contact to basement membrane,

Pseudostratified ciliated columnar

have cilia on apical surface and can be found in larger air passageways of respiratory system, larynx, pharynx, trachea and bronchi

Psedostratified nonciliated columnar

no cilia and can be found in male urethra and epididymis

Stratified squamous

multiple cell layers only the deepest layer in contact with basement membrane, protection of underlying tissue

Nonkeratinized stratified squamous

superficial cells are alive and kept moist, lining of oral cavity, part of pharynx, esophagus lining of vagina, and anus

. Keratinzed stratified squamous

apical cells are dead and filled with keratin, epidermis of skin

Stratified cuboidal

rare, two or more cell layers, cells of apical surface are columnar, protects and secretes, salivary glands, membranous part of male urethra

Stratified columnar

rare, two or more cell layers, cells of apical surface are columnar, protects and secretes, salivary glands, membranous part of male urethra

Transitional

different appearances depending on whether it is in a relaxed or distended state, important for distension and relaxation to accommodate urine volume, found in urinary bladder, ureters, and part of urethra

Glands

unicellular or multicellular organs composed of epithelial tissue important for secreting substances for use elsewhere or for elimination, secretions include mucin, electrolytes, hormones, enzymes, urea

Exocrine glands

originate form an invagination of epithelium that burrows into deeper connective tissue, connection with epithelium via duct a hollow tube into which gland secretes ( mammary glands, sweat glands, salivary glands

Unicellular glands

one cell and can be found in simple columnar and pseudostratified ciliated columnar goblet cells

Multicellular glands

numerous cells that work together to produce secretion

Simple glands

single unbranched duct

Compound glands

branched ducts

Merocrine

pack secretions into vesicles and secrete via exocytosis (lacrimal, salivary, sweat, pancreas and gastric glands

Apocrine

pinching off of apical portion of secretory cells and that becomes secretion (mammary glands, sweat glands (in axillary and pubic regions))

Holocrine

cells accumulate the product then the entire cells disintegrates and becomes secretion viscous mixture of cells products and product (sebaceous (oil) glands)

Connective Tissue

Most diverse, abundant, and widely distrib

Functions of connective tissue

o Support


o Protection


o Bind organs


storage


transport


immune protection

Resident cells

stationary cells permanently housed help support maintain and repair

Fibroblasts

most abundant, produce fibers and ground substance components of ECM

Adipocytes

fat cells collection of adipocytes= adipose tisse

Mesenchymal cells

embryonic stem cell upon damage these cells will divide and give rise to a mesenchymal cell and the differentiated damaged cell

Fixed macrophages

derived from monocytes, dispersed throughout and engulf damaged cells or pathogens upon encountering foreign material they secret chemicals that trigger the immune system

Wandering cells

components of immune system and are continuously moving throughout connective tissue (leukocytes)

Mast cells

small, mobile cells close to blood vessels, secret heparin (stop blood clotting) and histamine (dilate blood vessels)

Plasma cells

B lymphocytes, produce antibodies (proteins that immobilize a foreign material)

Free macrophages

mobile phagocytic that wander through the connective tissue (like fixed macrophages but are mobile)

Other leukocytes

migrate through the blood vessel to connective tissue (neutrophils, lymphocyte

Protein fibers

strengthen and support the tissue


o Viscous- thick in blood


o Semisolid- cartilage


o Solid- bone

Collagen fibers

unbranched, long fibers, strong, flexible, resistant to stretching, form 25% of body's protein appear white (white fibers) abundant in tendons and ligaments

Reticular fbers

thinner than collagen, same proteins as in collagen except that are coated with glycoproteins, branched, tough but flexible found in stroma of organs such as lymph nodes, spleen, and liver

Elastic fibers

made of protein of elastin, fibers branch and rejoin, important for stretch and recoil found in skin, lungs, arteries

Ground substance

nonliving material produced by the connective tissue cells, connective tissue cells and fibers reside in ground substance made of glycosaminoglycans, water, preoteoglycan, adherent glycoproteins, ground substance and fibers collectively make the ECM

Physical protection


bones of skull and thoracic cage protect vital organs

Support and structural framework


bones serve as framework for our body, cartilage keeps air tubes like trachea open

Binding of structures


ligaments bind bone to bone, tendons bind muscle to bone, dense connective tissue anchors skim to muscle and bone

Storage


adipose connective tissue- major energy reserve, bone- reserve for calcium and phosphorus

Transport


blood carries nutrients, gases, and wastes

Immune protection


leukocytes are abundant within connective tissue they protect the body against disease

Embryonic connective tissue

2 type


mesenchyme


mucous connective tissue

mesenchyme

origin of all connective types found throughout the body of embryo and fetus

mucous connective tissue

support of structures in umbilical cord found in umbilical cord of fetus

Loose Connective Tissue

fewer fibers, more ground substance

Loose Connective Tissue


Areolar

abundant, viscous ground substance, scattered fibroblasts, many blood vessels, protects tissues and organs, binds some epithelial to deep tissue, found in papillary layer of dermis, subcutaneous layer (deep skin), surrounds organs, nerves, and blood vessels

Loose Connective Tissue


Adipose

closely packed adipocytes, nucleus pushed to edge of cell by large fat droplet, stores energy insulates, cushions, and protects found in subcutaneous layer and surrounds and covers most organs

Loose Connective Tissue


Reticular

viscous ground substance, scattered arrangement of reticular fibers, fibroblasts and leukocytes, provides stroma to lymphatic organs therefore it is found in spleen, lymph nodes, thymus, and bone marrow

Dense Connective Tissue

more fibers, less ground substance

Dense Connective Tissue


Regular

densely packed, parallel arrays of collagen fibers, fibroblasts squeezed between layers of fibers, scarce ground substance, greatly reduced blood supply, attaches bone to bone (ligament), muscle to bone (tendon), resists stress applied in one direction

Dense Connective Tissue


Irregular

collagen fibers randomly arranged and clumped together, fibroblasts in spaces among fibers, more ground substance than in dense regular, extensive blood supply can withstand stresses applied in all directions found in most of dermis of skin, periosteum covering bone, covers cartilage

Dense Connective Tissue


Elastic

predominantly composed of elastic fibers and fibroblasts occupy some spaces between fibers, allows for stretching and recoil, found in walls of elastic arteries (aorta), trachea, vocal cords

Supporting Connective Tissue


Cartilage

semisolid matrix

Supporting Connective Tissue


Hyaline

glassy appearing matrix, sparsely arranged chondrocytes in lacunae, forms most of fetal skeleton provides support found in tip of nose, trachea, larynx, costal cartilage, articular ends of bones

Supporting Connective Tissue


Fibrocartilage

readily visible, numerous parallel collagen fibers, large chondrocytes in lacunae, resists compression and acts as a shock absorber in some joints, found in intervertebral discs, pubic symphysis, and menisci of knee joints

Supporting Connective Tissue


Elastic

abundant elastic fibers that form weblike mesh, chondrocytes in lacunae, functions to maintain shape while permitting extensive flexibility found in external ear and epiglottis of larynx

Bone

solid matrix (osseous

compact bone

calcified ECM containing osteocytes trapped in lacunae, arranged in osteons, provides levers for body movement, support soft structures, protects organs, stores calcium and phosphorus, found in bones

Spongy bone

different organization from compact bone, contains hemopoetic tissue and is the site of hemopoeisis found in bones

fluid connective tissue


Blood

composed of formed elements (erythrocytes, leukocytes, platelets) and plasma, important for transport of gases, nutrients, wastes, hormones, immune defense, found in blood vessels and heart

fluid connective tissue


lymph

derived from blood plasma and is

Muscle tissue

Composed of specialized cells that contract when stimulated by nervous system and produces movement

skeletal muscle

long cylindrical, striated fibers (cells) arranged in parallel and unbranched fibers are multinucleated under voluntary contraction, function in moving the skeleton, attaches to bones and sometimes to skin

Cardiac muscle

short striated cells typically branching uninucleated or binucleated intercalated discs between cells under involuntary control, pumps blood through heart found in heart wall (myocardium)

Smooth muscle

nonstriated cells that are short, uninucleated, move and propelling of material through the internal organs found in walls of hollow organs such as intestines, stomach, airways, stomach, urinary bladder, uterus and blood vessels

Nervous tissue

located within brain, spinal cord, and nerves, composed of neurons that receive, transmit, and process nerve impulses, also contains glial cells (supporting cells)

Neurons

contain cell body, cell processes, dendrites and axons

Tissues form organs which are composed of two or more tissue types that work together to perform specific, complex functions


examples

stomach-epithelium, areolar, dense, smooth muscle and nervous tissues

Body membranes

composed of epithelial layer bound to connective tissue, designed to line body cavities

All tissue develops from the 3 primary germ layers

endoderm, mesoderm, ectoderm

Endoderm

epithelial linging of respiratory tract, GI tract liver gall bladder, pancreas, thyroid and parathyroid glands

Medoderm

muscle, dermis of skin, epithelial lining of blood vessels, connective tissues, heart

ectoderm

epidermis of skin, nervous tissues, pituitary gland, adrenal medulla

Metaplasia

epithelium changing into mature epithelium

hypertrophy

an increase in size of existing cells

hyperplasia

an increase in number of cells in a tissue

necrosis

tissue death

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