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40 Cards in this Set

  • Front
  • Back
Endocrine glands and organs secrete hormones into the _______________
circulatory system
4 Main characteristics of endocrine system
Chemical signals
Carried by blood vessels
Slower response
Long-term response
The Endocrine system uses _________ to communicate between body parts
HORMONES
exocrine glands secrete products into ________ that lead to external environment.
Examples of exocrine glands:
,
ducts (endocrine doesn't use ducts)

Sebaceous gland, sweat gland, lingual glands, mammary gland
What three organs are both endocrine and exocrine?
Stomach, Liver, Pancreas
Exocrine function of the stomach?
Secrete into lumen of gastric gland
• Mucus cells - mucus
• Parietal cells - H+ and Cl-
• Chief cells - Pepsinogen
Endocrine function of the stomach?
• G-cells secrete gastrin into blood
• Gastrin stimulates HCl production

Coffee stimulates gastrin release increasing HCl in stomach
Exocrine function of the Liver
Secretes bile into lumen of bile duct
Endocrine function of the Liver
• Along with kidney, secretes thrombopoietin into blood
• Stimulates platelet production in bone marrow
(Megakaryocytopoiesis)
• Angiotensinogen: raises blood pressure
• insulin-like growth factor 1 (IGF-1) - important role in childhood growth
Exocrine function of the Pancreas
• Secretes bicarbonate and digestive enzymes into lumen of pancreatic duct (which goes into small intestine)
Endocrine function of the pancreas
Secretes insulin & glucagon into blood - regulates blood glucose level
Local regulators that secrete chemicals that affect nearby cells or themselves?

Are these chemicals hormones?
paracrine & autocrine

NOT hormones

Typically NOT considered part of the endocrine system since local effect only
Local regulators that cross synapses
Neurotransmitters
Released from specialized neurons of nervous system organs into the blood
Neurohormones
Epinephrine's effect on the following:

Liver
Skeletal muscle blood vessel
Intestinal blood vessel
-Liver: stimulates breakdown of glycogen and glucose is released
-Skeletal muscle blood vessel: stimulates dilation
-Intestinal blood vessel: stimulates constriction
________& _______ control much of endocrine system
Hypothalamus & Pituitary
Does the posterior pituitary gland synthesize hormones?
What hormones does it secrete?
NO, it stores and secretes hormones made by the hypothalamus

ADH and Oxytocin
Anterior pituitary gland controlled by hormones delivered directly from ____________ (vs. post pit which is controlled by nerve impulse from ______________)
hypothalamus

hypothalamus
regulate other endocrine organs (FSH, LH, TSH, ACTH)
Tropic hormones
hormones directly stimulate target cells to induce effects (Prolactin, MSH)
Non-tropic
Some ant. pit. hormones have both tropic & non-tropic effects, example?
Growth hormone
Tropic effect of Growth hormone?

Non-tropic?
Tropic -Induces liver to release IGF-1 which regulates bone growth

Non-tropi - Acts directly on muscles to stimulate growth
Gigantism, Dwarfism and Acromegaly are due to ?
Abnormal levels of growth hormone
The Thyroid absorbs and stores _______?

Produces and secretes ?
-Iodine

-T3, T4, and Calcitonin
______ is converted in to ______ in the liver, kidney, spleen using _______?
T4 converted to T3 using selenium
Function of T3 and T4?

Which one is more stable? Most present in blood? Which one is more active?
-Regulation of blood pressure, heart rate, digestion, reproduction

-T4 more stable and more present in blood

-T3 more active
Function of Calcitonin? Where is it produced?
Increased Ca2+ causes calcitonin release --> calcitonin Inhibits uptake of Ca2+ from small intestine and inhibits Ca2+ release from bones
Autoimmune disease
Antibody binds to TSH receptor on anterior pituitary
Causes too much T3/T4 to be made
5-10x more common in women
Grave’s disease
Normally, increased T3/T4 in blood causes decreased _______ but w/ goiter, lack of T3/T4 leads to high _______ since no neg feedback
-TSH

-TSH
Type 1 diabetes
low insulin production

appears during childhood
Type 2 diabetes
Insulin receptor on target body/liver cells malfunction so don’t uptake glucose
Usually occurs after age 40 but obesity lowers age
The posterior pituitary gland is controlled by?
controlled by nerve impulse from hypothalamus
The anterior pituitary is controlled by?
Controlled by hormones delivered directly from hypothalamus
T3 and T4 are made form?
tyrosine and iodine
T4 is converted to T3 where?
in liver, kidney, spleen using selenium (a mineral)
Where is calcitonin produced?
Produced in C-cells of thyroid
____________ causes calcitonin release
Increased Ca2+
Function of calcitonin?
•Inhibits uptake of Ca2+ from small intestine

•Inhibits Ca2+ release from bones
hyperthyroidism disease?
grave's disease
Autoimmune disease
Antibody binds to TSH receptor on anterior pituitary
Causes too much T3/T4 to be made
Grave's disease