Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
|
BONE DISORDERS
BONE DISORDERS BONE DISORDERS BONE DISORDERS |
BONE DISORDERS
|
|
|
OSTEOGENESIS IMPERFECTA (OGI)
|
"BRITTLE BONE" DISEASE
Auto Dominant |
|
|
OSTEOGENESIS IMPERFECTA
has a defect in: |
synthesis of TYPE 1 COLLAGEN
|
|
|
Clinical findings of OSTEOGENESIS IMPERFECTA
|
1. Blue Sclera
2. deafness |
|
|
VIP BQ:
OSTEOGENESIS IMPERFECTA MOA OF BLUE SCLERA IN OGI |
IS THE REFLECTION OF UNDERLYING CHOROIDAL VEINS
(there is collagen in sclera & b/c collagen synthesis is defective in OGI, the sclera is very thin.) |
|
|
OSTEOPETROSIS
|
"MARBLE BONE" DISEASE
AR |
|
|
OSTEOPETROSIS
defect in: |
osteoclasts
"too much bone": overgrowth of and sclerosis of cortical bone can't break down bone |
|
|
OSTEOPETROSIS
2 clinical findings |
1. ANEMIA:
because you don't have marrow 2. CRANIAL NERVE COMPRESSION visual & hearing loss |
|
|
OSTEOPOROSIS
|
OSTEOPOROSIS
|
|
|
OSTEOPOROSIS
Is most common |
metabolic abnormality of bone
|
|
|
D: OSTEOPOROSIS
|
is the overall reduction of bone mass in BOTH mineral and organic components
|
|
|
POSTMENOPAUSAL OSTEOPOROSIS:
is due to: explain MOA |
Estrogen deficiency
MOA: estrogen inhibits production of ostoclasts and enhances osteoblasts |
|
|
POSTMENOPAUSAL OSTEOPOROSIS:
clinical findings (MC?) |
1. COMPRESSION FRACTURES OF VERTEBRAL BODIES
2. COLLES' FRACTURE OF DISTAL RADIUS |
|
|
name the osteoclast activating factor
|
IL-1
|
|
|
VIP BQ: OSTEOPOROSIS:
IS SWIMMING A GOOD EXERCISE TO PREVENT OSTEOPOROSIS? |
NO! b/c it does not stress bones... you need stress bone to build it up
GOOD ONES: 1. WALKING 2. WEIGHTS |
|
|
POSTMENOPAUSAL OSTEOPOROSIS
prevention |
1. 1500mg Calcium
2. 400-800 vitamin D supplements |
|
|
OSTEOPOROSIS
test |
Dual--photon absorptiometry
non-invasive evaluates bone density |
|
|
TUMORS OF BONE
TUMORS OF BONE TUMORS OF BONE TUMORS OF BONE |
TUMORS OF BONE
|
|
|
BENIGN TUMORS OF BONE
|
BENIGN TUMORS OF BONE
|
|
|
OSTEOCHONDROMA
|
OVERALL MC bone tumor
|
|
|
EPID
OSTEOCHONDROMA |
M
10-30y/o single or multiple |
|
|
OSTEOCHONDROMA
primary location |
metaphysis of distal femur
|
|
|
OSTEOCHONDROMA
characteristics |
outgrowth of bone capped by benign cartilage
|
|
|
ENCHONDROMA
EPID |
m=f
20-50 y/o solitary or multiple |
|
|
ENCHONDROMA
primary location |
medullary location
Small tubular bones in hands and feet |
|
|
ENCHONDROMA
characteristics |
multiple enchondromas
risk for chondrosarcoma |
|
|
MALIGNANT BONE TUMORS
|
MALIGNANT BONE TUMORS
|
|
|
CHONDROSARCOMA
primary location |
pelvic bones
proximal femur |
|
|
CHONDROSARCOMA
characteristics |
grade determines biologic behavior
metastasizes to LUNGS MC malignant cartilage tumor |
|
|
CHONDROSARCOMA
EPID |
M
30-60 |
|
|
OSTEOGENIC SARCOMA
KEY WORDS |
ADOLESCENT
KNEE SUNBURST APPEARANCE CODMAN'S TRIANGLE |
|
|
OSTEOGENIC SARCOMA
genetics |
RB suppressor gene
chromosome 13 |
|
|
OSTEOGENIC SARCOMA
Risk factors |
Paget's disease
familial retinoblastoma irradiation |
