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21 Cards in this Set
- Front
- Back
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MACULAR PETECHIAE
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< OR EQUAL TO 4 MM
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INTERMEDIATE MACULAR PURPURA
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4 - 10 MM
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MACULAR ECCHYMOSIS
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> 10 MM
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PURPURA
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CLASSIC PALPABLE PURPURA (TARGET LESIONS)
INFLAMMATORY RETIFORM PURPURA NON-INFLAMMATORY RETIFORM PURPURA |
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PRIMARY HEMOSTASIS
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PLATELET PLUG
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SECONDARY HEMOSTASIS
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CLOT
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LCCV VS OCCLUSIVE
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LCCV: LESIONS PEAK 24 - 48 HRS
NO FIBRIN < 1 DAY OCCLUSIVE: MAX PURPURA < 1 DAY, THEN INCREASE PAPABLE 1 - 3 DAYS FIBRIN < 1 DAY |
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LCCV 0 - 24 HOURS
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IMMUNE-COMPLEX MEDIATED LEUKOCYTOCLASTIC VASCULITIS LESIONS
MILD PALPABLE, MILD ERYTHEMA, TRACE PURPURA NO FIBRIN COMPLEMENT ATTRACTS PMNS |
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LCCV 24 - 48 HRS
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MAX LESIONS
PALPABLE PURPRUA, ERYTHEMA PMNS, NUCLEAR DUST, FIBRIN FIBROID NECORSIS |
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LCCV > 2 DAYS
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DECREASE PALPABLE, ERYTHEMA, PURPURA STABLE, FEW OR NO PMNS
+ MONONUCLEAR CELLS INFLAMMATION STOPS, FIBRIN SLOWLY CLEARED |
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MICROVASCULAR OCCLUSION RELATED LESIONS
0 TO FEW HOURS |
NO PALPABLE, INCREASING PURPURA
SLOW BLUE FLOW SOME RBCS, NO INFLAMMATION EARLY ISCHEMIA WITH VESSEL LEAKAGE, EDEMA, FIBRIN |
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MICROVASCULAR OCCLUSION FEW HOURS TO 24 HOURS
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MILD PALPABLE, PURPURA MAX, NO ERYTHEMA, SOMETIMES ECHAR, BLAND OCCLUSION, MANY RBCS, RARE PMNS, OCCLUSION PEAKS, ICHEMIA MAXIMAL, RBCS, CLOT
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MICROVASCULAR OCCLUSION 1 - 4 DAYS
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PALPABLE, PURPURA SLOWLY CLEARS, CAN SEE SOME ERYTHEMA WITH WOUND HEALING RESPONSE, OR SC OR DERMAL TISSUES INVOLVED HEAPRIN COUMADIN NECROSIS, ANTIPHOSPHOLIPID AB SYNDROME, CUTANEOUS CALCIPHYLASXIS
LCCV AT WOUND EDGE WOUND RESPONSE MAY CAUSE SECONDARY VASCULITIS |
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VITAMIN K DEPENDENT COAGULATION FACTORS
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2, 7, 9, 10, C AND S
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VITAMIN K DEPENDENT COAGULATION FACTORS
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2,7,9,10,C,S
FACTORS ARE MODIFIED BY VITAMIN-K DEPENDENT POST TRANSLATIONAL CARBOXYLATION OF GLUTAMIC ACID RESIDUES PROTEINS BIND CA AND PHOSPHOLIPIDS ALLOWS THEM TO FXN ON PLASMA MEMBRANE |
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FACTORS INACTIVATED BY PROTEIN C?
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5,8
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HIGH PT AND NORMAL PTT
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FACTOR 7 DEFICIENCY
COUMADIN |
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HIGH PTT AND NORMAL PT
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VONWILLEBRANDS, LUPUS ANTICOAGULANT, HEAPRIN AQUIRED FACTOR 13 INHIBITOR, FACTOR 12, 11, OR 8 DEF, HMWK, OR PK
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COMBINED HIGH PT AND PTT
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DEF FIBRINOGEN, THROMBIN, FACTORS 5 OR 10
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LUPUS ANTICOAGULANT TEST?
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RUSSEL-VIPER VENOM TEST
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5 VARIANTS OF PIGMENTED PURPURAS
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1. SCHAMBERG'S
2. PURPURA ANNULARIS TELANGIECTODES OF MAJOCCHI 3. PIGMENTED PURPURIC LICHENOID DERMATITIS OF GOUGEROT AND BLUM 4. ECZEMATID-LIKE PURPURA OF DOUCAS AND KAPETANAKIS 5. LICHEN AUREUS |
