Bocock Uworld 1.1

Front 1

What gut abnormality is associated with trisomy 21-downs syndrome?

Back 1

duodenal atresia

Front 2

What gut abnormality results from the failure of neural crest cell migration into the intestinal wall?

Back 2

Hirschsprung disease

Front 3

Type of hernia common in children that occurs due to a weakness of the abdominal wall at the umbilicus?

Back 3

umbilical hernia

Front 4

This condition occurs due to abnormal development of anorectal structures and manifests during the first few days of life when the newborn fails to pass meconium?

Back 4

Imperforate anus

Front 5

Gut abnormality where organs protrude through a abdominal wall defect and are covered with a peritoneal sac?

Back 5

omphalocele

Front 6

This is failure of the midgut to rotate counter-clockwise as it returns to the abdominal cavity during embryonic development?

Back 6

malrotation

Front 7

The most common vitelline duct anomally which results from a partial closure of the vitelline duct, with the patent portion attached to the ileum-a fibrous band may connect this anomally to the umbilicus?

Back 7

meckel diverticulum

Front 8

The rule of 2's with meckel diverticulum?

Back 8

2% of population 2 feet from the ileocecal valve 2 inches in length 2% are symptomatic males are 2xs more likely to be affected

Front 9

What two gut anomalies result when the omphalomesenteric (vitelline) duct fails to obliterate during the 7th week of developement?

Back 9

enterocysts meckel diverticula

Front 10

What are 3 prominent features of marfan's syndrome?

Back 10

long-thin extremeties-arachnodactyly occular abnormalities-dislocation of the lens cardiovascular abnormalities-including aortic aneurysm, aortic dissection, and mitral valve prolapse

Front 11

This syndrome is due to a defect in fibrillin-an extracellular glycoprotein that is abundant in the zonular fibers of the lens, periosteum, and the aortic media?

Back 11

marfan's syndrome

Front 12

Bone abnormality caused by impaired osteoclastic bone resorption and is characterized by increased bone thickness and density?

Back 12

osteopetrosis

Front 13

This arthritic disease results in fusion of the spine and sacroiliac joints as well as arthritis of the hips, shoulders, and costochondral joints-it's also associated with HLA-B27?

Back 13

ankylosing spondylitis

Front 14

This bone disease results from defects in genes encoding type 1 collagen-results in fractures, blue sclera, and dental abnormalities?

Back 14

osteogenesis imperfecta

Front 15

One of the most common causes of dwarfism and results from a genetic defect in the fibroblast growth factor receptor 3 gene?

Back 15

achondroplasia

Front 16

The primary dfect of this condition is abnormal chondrocyte proliferation at the growth plates of long bones-causes short limbed dwarfism?

Back 16

achondroplasia

Front 17

An autosomal recessive disorder resulting from a defect in DNA repair genes-the DNA of these patients is hypersensitive to ionizing radiation?

Back 17

Ataxia-telangiectasia

Front 18

Manifestations of ataxia-telangiectasia?

Back 18

cerebellar ataxia oculocutaneous telangiectasias repeated respiratory infections increased incidence of malignancy

Front 19

In this disease, neurofibrillary tangles are seen in the neocortex?

Back 19

alzheimer's disease

Front 20

Loss of neurons in the substantia nigra is characteristic of this disease?

Back 20

parkinson disease

Front 21

Atrophy of the caudate nucleus is seen in this disease?

Back 21

huntington's disease

Front 22

Posterior column degeneration can be seen in these two conditions?

Back 22

vit B12 deficiency syphilis

Front 23

The presence of lewy bodies and loss of neurons in the substantia nigra are associated with this disease?

Back 23

parkinson disease

Front 24

Name 5 inherited disorders caused by deficient DNA repair enzymes?

Back 24

ataxia telangiectasia xeroderma pigmentosum fanconi anemia bloom syndrome hereditary nonpolyposis colorectal cancer (HNPCC)

Front 25

This coniditon arises due to a defect in DNA mismatch repair enzymes and leads to an increased susceptibility to colon cancer?

Back 25

hereditary nonpolyposis colorectal cancer (HNPCC)

Front 26

This condition is associated with hypersensitivity of DNA to crosslinking agents?

Back 26

fanconi anemia

Front 27

In this condition, DNA is hypersensitive to UV radiation causing premature skin aging and an increased risk of skin cancer?

Back 27

xeroderma pigmentosum

Front 28

Name three measures of central tendency?

Back 28

median, mean, and mode

Front 29

This value is the number that seperates the right half of an ordered data set from the left half?

Back 29

median

Front 30

What is the median of the data set 75, 75, 80, 90, 110, and 110?

Back 30

(80+90/2)=85

Front 31

To find this value, you add all of the observations of a data set and divide that sum by the number of observations?

Back 31

mean

Front 32

This is the most frequent value of a data set?

Back 32

mode

Front 33

This molecule is a portion of proinsulin. It is packaged with insulin into secretory granules and is secreted in equimolar concentrations with insulin?

Back 33

c peptide

Front 34

What are some risk factors for osteoporosis; AKA: decreased bone mass?

Back 34

smoking menopause corticosteroid therapy physical inactivity caucasian race low body weight alcohol use

Front 35

In what organ does hypoxemia cause a vasoconstrictive response?

Back 35

the lung

Front 36

What is unique about the pulmonary vascular bed?

Back 36

it vasoconstricts during hypoxemia to divert blood away from underventilated areas

Front 37

Type of viral gene exchange that occurs through the crossing over of two double stranded DNA molecules?

Back 37

recombination

Front 38

This process describes the mixing of genome segements in two or more segemented viruses that infect the same host cell?

Back 38

reassortment