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15 Cards in this Set
- Front
- Back
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COMPONENTS OF FBC
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WCC (+type) MCV Platelets |
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ANAEMIA - DEFINITION
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Men: <130g/L Women: <120g/L |
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MICROCYTIC ANAEMIA |
Due to: Iron deficiency - mentstruation, GI bleed, coeliac Thalassaemia Chronic disease (affects bone marrow function) |
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NORMOCYTIC ANAEMIA
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Due to: Early iron/vitamin deficiency Chronic disease (affects bone marrow function) Renal failure (decreased EPO) |
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MACROCYTIC ANAEMIA
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Due to: B12 deficiency (pernicious anaemia, crohns) Folate deficiency (dietary, alcohol excess) Alcohol excess (effects bone marrow and folate) Hypothyroidism Haemolysis (leads to increased red cell turnover but immature) |
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INCREASED HAEMOGLOBIN
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Due to: Dehydration Alcohol Smoking Polycythaemia vera (autoimmune) |
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CHANGES TO WCC
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Up: infection, trauma, leukaemia Down: neutropenia in chemo, infection |
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CHANGES TO PLATELETS |
Down: THROMBOLYSIS; liver disease, ITP or viral infection |
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LFTs: WHAT AND COMPONENTS
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Bilirubin AST/ALT AlkPhos GammaGT |
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SYNTHETIC LFTS
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Bilirubin Albumin Prothrombin time |
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LIVER SCREEN |
Ferritin Caeruloplasmin (Wilson's) a1-antitrypsin Autoantibodies Igs HepB+C serology Lipids a-fetoprotein (HCC) |
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ALT & AST
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AST: aspartate aminotransferase; in liver, heart, skeletal muscle, kidneys, brain and RBC Give hepatic picture |
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ALK PHOS
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Marker of cholestasis (cholestatic picture) Found in cholangiocytes but also bones |
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GAMMA GT
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Sensitive but not specific Increased in any liver disease including alcohol excess Marker for confirming if AlkPhos if from bones or liver |
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NORMAL RANGES FOR LFTS
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ALT/AST: 40ul AlkPhos: 90ul PT: <15 |
